WO2003033007A1 - Compositions pharmaceutiques pour utilisation topique contenant des extraits de plantes medicinales avec actions antiphlogistiques et cicatrisantes - Google Patents
Compositions pharmaceutiques pour utilisation topique contenant des extraits de plantes medicinales avec actions antiphlogistiques et cicatrisantes Download PDFInfo
- Publication number
- WO2003033007A1 WO2003033007A1 PCT/EP2002/011357 EP0211357W WO03033007A1 WO 2003033007 A1 WO2003033007 A1 WO 2003033007A1 EP 0211357 W EP0211357 W EP 0211357W WO 03033007 A1 WO03033007 A1 WO 03033007A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- flowers
- malva
- althaea
- cicatrising
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/577—Malvaceae (Mallow family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Definitions
- the present invention relates to pharmaceutical compositions for the topical use containing extracts of chamomile heads (Matricaria recutita), althaea roots (Althaea officinalis L.), malva flowers (Malva sylvestris), large- leaved lime flowers (Tillia Platyphyllos) and milfoil flowers (Achillea millefolium L.), endowed with anti-inflammatory and cicatrising properties, for the treatment of skin inflammations and lesions.
- chamomile heads Matricaria recutita
- althaea roots Althaea officinalis L.
- malva flowers Malva sylvestris
- large- leaved lime flowers Tala Platyphyllos
- milfoil flowers Adchillea millefolium L.
- bedsores i.e. skin lesions which, due to reduced tissutal perfusion and loss of skin trophism and elasticity, tend to become chronic, is one of the most widespread consequences of protracted infirmity, especially in the elderly.
- the accumulation of free radicals reduces the tensile strength of the lesions by inhibiting hyaluronic acid, thus preventing tissutal reparative processes.
- Healing of skin lesions apparently occurs through a first "inflammatory" phase followed by a neo-angiogenesis and granulation tissue formation phase, with wound contraction and subsequent cicatrization and re-epithelization.
- Object of the present invention are pharmaceutical compositions for topical use containing extracts of chamomile heads (Matricaria recutit ⁇ ), althaea roots (Althaea officinalis L.), malva flowers (Malva sylvestris), large-leaved lime flowers (Tillia Platyphyllos) and milfoil flowers (Achillea millefolium L.), useful for the treatment of skin infiammations and lesions.
- extracts of chamomile heads (Matricaria recutit ⁇ ), althaea roots (Althaea officinalis L.), malva flowers (Malva sylvestris), large-leaved lime flowers (Tillia Platyphyllos) and milfoil flowers (Achillea millefolium L.), useful for the treatment of skin infiammations and lesions.
- Said pharmaceutical compositions are preferably in the form of creams, gels, pastes or ointments, in which the extracts total content ranges from 10 to 40%.
- a preferred embodiment of the invention consists in a cream containing 20% extracts in Essex ® base cream (hereinafter referred to as BAR 2).
- BAR 2 The compositions can be prepared from extracts of each vegetable component, or from an extract obtainable from a mixture of all the vegetable components.
- the liquid phase is recovered by filtration, preferably under vacuum, and evaporated under reduced pressure at a temperature not higher than 35°C.
- 100 g vegetable components mixture is soaked in a 30/70 v/v distilled water/ethanol mixture, up to 1 litre final volume.
- BAR 1 The anti-inflammatory and cicatrising properties of the compositions containing the extracts of the invention were evaluated in rats by means of the following tests:
- Both the extract and the cream showed active, in fact topical application on rat skin reduced in a statistically significant way inflammation and oedema in the carrageenin and dextran oedema tests and enhanced the cicatrising action in the experimental excoriations and ulcers tests.
- BAR 1 extract was prepared soaking for 24 hours a mixture consisting of 100 g of each vegetable component, suitably ground, in distilled water and ethyl alcohol (30:70 v/v), to a final volume of one litre, stored in a tightly sealed dark vessel.
- the liquid phase was recovered by filtration under vacuum and the intense green liquid was evaporated under reduced pressure at a temperature of 30-35°C, to avoid degradation.
- Cream BAR 2 was prepared incorporating 20 g of BAR 1 extract in
- mice Male Sprague-Dawley rats, (about 120-150 g weight) purchased from Harlan Italy (Udine, Italy), housed in single cages, under controlled temperature and humidity (22 ⁇ 1°C, 60% humidity).
- Treatments BAR 1 extract or Cream BAR 2 were applied on the area to be treated.
- a suspension of carrageenin (0.1 ml, 1% in normal saline) was administered to one of the rats hind paws.
- leg volume was evaluated with a pletismometer (Basile, Varese), prior to carrageenin injection (reference value) and after 2, 4, 8, 24 hours.
- the values reported in the table refer to percentage increases in the paw volume compared with the reference value.
- BAR 1 extract was applied to the rat paw immediately after carrageenin injection and after each evaluation. Dextran oedema test
- a 5% dextran solution (0.1 ml) in saline was administered to one of the rats hind paws.
- leg volume was evaluated with a pletismometer (Basile, Varese), prior to dextran injection (reference value) and after 2, 4, 8, 24 hours.
- the values reported in the table refer to percentage increases in the leg volume compared with the reference value.
- BAR 1 extract was applied to the rat paw immediately after carrageenin injection and after each evaluation.
- Ketavet (Gellini pharmaceutical), then shaved on the back so as to define a 1.5 cm diameter circular area. After that, the skin was scarified with a scalpel, then Essex ® base cream was applied to control animals, whereas BAR 2 was applied to the treated ones.
- Table 1 shows that in a 24 hours evaluation BAR 1 reduces carrageenin-induced oedema in a statistically significant way compared with controls, at any surveying time.
- BAR 1 significantly reduces (table 2) the percentage of paw volume increase induced by dextran, and is particularly active between 4-6 hours.
- Table N°l Effect induced by BAR 1 on carrageenin oedema in rats
- Table 3 shows that BAR 2 accelerates cutaneous reparative processes subsequent to excoriations. Values observed at 48, 72 and 96 hours from excoriations are in fact much higher in treated animals than in controls. In particular, the effect is statistically significant at 72 and 96 hours.
- the results show that BAR 1 extract and the topical pharmaceutical compositions containing it have excellent antiphlogistic and cicatrising activities. Therefore, the pharmaceutical compositions containing the extracts of the invention, in particular BAR 1 extract, can be used in the treatment of skin conditions wherein reduction of inflammation and improvement of tissue repair processes are required, in particular for healing bedsores.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2001A002142 | 2001-10-17 | ||
IT2001MI002142A ITMI20012142A1 (it) | 2001-10-17 | 2001-10-17 | Composizioni farmaceutiche per uso topico contenenti estratti di erbemedicinali ad attivita' antilogistica e cicatrizzante |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003033007A1 true WO2003033007A1 (fr) | 2003-04-24 |
Family
ID=11448511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/011357 Ceased WO2003033007A1 (fr) | 2001-10-17 | 2002-10-10 | Compositions pharmaceutiques pour utilisation topique contenant des extraits de plantes medicinales avec actions antiphlogistiques et cicatrisantes |
Country Status (2)
Country | Link |
---|---|
IT (1) | ITMI20012142A1 (fr) |
WO (1) | WO2003033007A1 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006047470A3 (fr) * | 2004-10-26 | 2006-06-22 | Johnson & Johnson Consumer | Compositions contenant un extrait de malva sylvestris et utilisation de ces compositions sur des tissus muqueux |
WO2007112204A3 (fr) * | 2006-03-23 | 2007-11-29 | Johnson & Johnson Consumer | Extraits contenant des compositions pouvant être ingérées |
EP1967187A1 (fr) | 2007-03-06 | 2008-09-10 | Rachid Ennamany | Composition à base de rutine et de L-lysine |
JP2008285424A (ja) * | 2007-05-15 | 2008-11-27 | Maruzen Pharmaceut Co Ltd | プロフィラグリン産生促進剤、フィラグリン産生促進剤及びシクロオキシゲナーゼ−2活性阻害剤 |
WO2008146009A1 (fr) | 2007-06-01 | 2008-12-04 | Insignion Holdings Limited | Extrait végétal et son utilisation thérapeutique |
KR100967018B1 (ko) | 2003-04-09 | 2010-06-30 | 애경산업(주) | 식물 추출물을 함유한 피부 미백 화장료 |
US20150265668A1 (en) * | 2011-05-16 | 2015-09-24 | Haus Bioceuticals, Inc. | Compositions of herbal formulations and uses thereof |
EP3150213A1 (fr) | 2015-10-01 | 2017-04-05 | Braerg - Groupo Brasileiro de Pesquisas Especializadas Ltda | Une composition médicale ayant un effet antibiotique, anti-inflammatoire et cicatrisant les plaies |
ITUB20160058A1 (it) * | 2016-01-19 | 2017-07-19 | Farm S R L C U S | Composizione di un preparato per il trattamento delle punture di insetto con attivita’ vasocostrittiva, lenitiva, disinfiammante e disarrossante |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4933177A (en) * | 1981-02-27 | 1990-06-12 | Societe Anonyme Dite: L'oreal | Cosmetic compositions for the treatment of the hair and skin contain in the form of a powder particles resulting from the pulverization of at least one plant substance and a cohesion agent |
RU1561262C (ru) * | 1980-10-13 | 1994-10-30 | Научно-производственное объединение "ВНИИ лекарственых и ароматических растений" | Состав, обладающий противовоспалительной активностью "ротокан |
WO1998034591A1 (fr) * | 1997-02-11 | 1998-08-13 | The Procter & Gamble Company | Compositions pour reduire l'hyperpigmentation de la peau |
US5876703A (en) * | 1994-12-02 | 1999-03-02 | Kao Corporation | Flavanonol derivatives and hair-nourishing, hair-growing compositions containing the derivatives |
-
2001
- 2001-10-17 IT IT2001MI002142A patent/ITMI20012142A1/it unknown
-
2002
- 2002-10-10 WO PCT/EP2002/011357 patent/WO2003033007A1/fr not_active Ceased
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU1561262C (ru) * | 1980-10-13 | 1994-10-30 | Научно-производственное объединение "ВНИИ лекарственых и ароматических растений" | Состав, обладающий противовоспалительной активностью "ротокан |
US4933177A (en) * | 1981-02-27 | 1990-06-12 | Societe Anonyme Dite: L'oreal | Cosmetic compositions for the treatment of the hair and skin contain in the form of a powder particles resulting from the pulverization of at least one plant substance and a cohesion agent |
US5876703A (en) * | 1994-12-02 | 1999-03-02 | Kao Corporation | Flavanonol derivatives and hair-nourishing, hair-growing compositions containing the derivatives |
WO1998034591A1 (fr) * | 1997-02-11 | 1998-08-13 | The Procter & Gamble Company | Compositions pour reduire l'hyperpigmentation de la peau |
Non-Patent Citations (4)
Title |
---|
AERTGEERTS, J.: "Résultats obtenus avec le Kamillosan(R), un extrait standardisée de camomille, en pratique dermatologique", ARS MEDICI, vol. 39, 1984, pages 65 - 68, XP001122220 * |
DATABASE WPI Section Ch Week 199523, Derwent World Patents Index; Class B04, AN 1995-176551, XP002228065 * |
DELLA LOGGIA R ET AL: "THE ROLE OF FLAVONOIDS IN THE ANTIINFLAMMATORY ACTIVITY OF CHAMOMILLA-RECUTITA", PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH, 1986, pages 481 - 484, XP001122218, ISSN: 0361-7742 * |
TUBARO A ET AL: "EVALUATION OF ANTIINFLAMMATORY ACTIVITY OF A CHAMOMILE CHAMOMILLA-RECUTITA EXTRACT AFTER TOPICAL APPLICATION", PLANTA MEDICA, vol. 51, no. 4, 1984, pages 359, XP009004098, ISSN: 0032-0943 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100967018B1 (ko) | 2003-04-09 | 2010-06-30 | 애경산업(주) | 식물 추출물을 함유한 피부 미백 화장료 |
WO2006047470A3 (fr) * | 2004-10-26 | 2006-06-22 | Johnson & Johnson Consumer | Compositions contenant un extrait de malva sylvestris et utilisation de ces compositions sur des tissus muqueux |
US7754248B2 (en) | 2004-10-26 | 2010-07-13 | Johnson & Johnson Consumer Companies, Inc. | Ingestible compositions containing extracts |
WO2007112204A3 (fr) * | 2006-03-23 | 2007-11-29 | Johnson & Johnson Consumer | Extraits contenant des compositions pouvant être ingérées |
EP1967187A1 (fr) | 2007-03-06 | 2008-09-10 | Rachid Ennamany | Composition à base de rutine et de L-lysine |
JP2008285424A (ja) * | 2007-05-15 | 2008-11-27 | Maruzen Pharmaceut Co Ltd | プロフィラグリン産生促進剤、フィラグリン産生促進剤及びシクロオキシゲナーゼ−2活性阻害剤 |
CN101687001A (zh) * | 2007-06-01 | 2010-03-31 | 因塞尼昂控股有限公司 | 植物提取物及其治疗用途 |
WO2008146009A1 (fr) | 2007-06-01 | 2008-12-04 | Insignion Holdings Limited | Extrait végétal et son utilisation thérapeutique |
AU2008256536B2 (en) * | 2007-06-01 | 2011-04-21 | Insignion Holdings Limited | Plant extract and its therapeutic use |
RU2438692C2 (ru) * | 2007-06-01 | 2012-01-10 | Инсайнион Холдингз Лимитед | Растительный экстракт и его терапевтическое применение |
US8591966B2 (en) | 2007-06-01 | 2013-11-26 | Insignion Holdings Limited | Composition containing oils of chamomile flower and black cumin with reduced endotoxins |
US20150265668A1 (en) * | 2011-05-16 | 2015-09-24 | Haus Bioceuticals, Inc. | Compositions of herbal formulations and uses thereof |
US9889174B2 (en) * | 2011-05-16 | 2018-02-13 | Haus Bioceuticals, Inc. | Compositions of herbal formulations and uses thereof |
EP3150213A1 (fr) | 2015-10-01 | 2017-04-05 | Braerg - Groupo Brasileiro de Pesquisas Especializadas Ltda | Une composition médicale ayant un effet antibiotique, anti-inflammatoire et cicatrisant les plaies |
ITUB20160058A1 (it) * | 2016-01-19 | 2017-07-19 | Farm S R L C U S | Composizione di un preparato per il trattamento delle punture di insetto con attivita’ vasocostrittiva, lenitiva, disinfiammante e disarrossante |
Also Published As
Publication number | Publication date |
---|---|
ITMI20012142A1 (it) | 2003-04-17 |
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