WO2003033530A3 - Mycobacterial antigens expressed under high oxygen tension - Google Patents
Mycobacterial antigens expressed under high oxygen tension Download PDFInfo
- Publication number
- WO2003033530A3 WO2003033530A3 PCT/GB2002/004647 GB0204647W WO03033530A3 WO 2003033530 A3 WO2003033530 A3 WO 2003033530A3 GB 0204647 W GB0204647 W GB 0204647W WO 03033530 A3 WO03033530 A3 WO 03033530A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- genes
- induced
- mycobacterial
- oxygen tension
- identifying
- Prior art date
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 230000001105 regulatory effect Effects 0.000 abstract 4
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 1
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000002853 nucleic acid probe Substances 0.000 abstract 1
- 229940023146 nucleic acid vaccine Drugs 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A method is provided for identifying mycobacterial genes the expression of which is induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of at least 30 % air saturation measured at 37 °C when compared with a dissolved oxygen tension of up to 10 % air saturation measured at 37 °C. The described method optionally provides for identifying mycobacterial genes that are simultaneously induced or up-regulated under continuous culture conditions that are iron-limiting. Said induced or up-regulated genes form the basis of nucleic acid vaccines, or provide targets to allow preparation of attenuated mycobacteria for vaccines against mycobacterial infections. Similarly, peptides encoded by said induced or up-regulated genes are employed in vaccines. In a further embodiment, the identified genes/peptides provide the means for identifying the presence of a mycobacterial infection in a clinical sample by nucleic acid probe or antibody detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002337287A AU2002337287A1 (en) | 2001-10-12 | 2002-10-14 | Mycobacterial antigens expressed under high oxygen tension |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0124593.5A GB0124593D0 (en) | 2001-10-12 | 2001-10-12 | Mycobacterial antigens expressed under high oxygen tension |
| GB0124593.5 | 2001-10-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003033530A2 WO2003033530A2 (en) | 2003-04-24 |
| WO2003033530A3 true WO2003033530A3 (en) | 2004-02-26 |
Family
ID=9923760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2002/004647 WO2003033530A2 (en) | 2001-10-12 | 2002-10-14 | Mycobacterial antigens expressed under high oxygen tension |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002337287A1 (en) |
| GB (1) | GB0124593D0 (en) |
| WO (1) | WO2003033530A2 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ519395A (en) * | 2002-06-07 | 2004-04-30 | Agres Ltd | Techniques for identifying genes that are important for virulence in Mycobacterial vaccines |
| US7608277B2 (en) * | 2004-12-01 | 2009-10-27 | Gene Therapy Systems, Inc. | Tuberculosis nucleic acids, polypeptides and immunogenic compositions |
| EP1910410B1 (en) * | 2005-07-01 | 2011-10-26 | Forsyth Dental Infirmary for Children | Tuberculosis antigen detection assays and vaccines |
| WO2007087679A1 (en) * | 2006-01-31 | 2007-08-09 | Proteome Systems Limited | Methods of diagnosis and treatment of m. tuberculosis infection and reagents therefor v |
| EP2441493B1 (en) * | 2006-03-14 | 2014-05-07 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
| CN102713629B (en) * | 2009-11-20 | 2016-02-24 | 俄勒冈健康科学大学 | Method for detecting Mycobacterium tuberculosis infection |
| CN103122364A (en) * | 2011-11-21 | 2013-05-29 | 华中农业大学 | Antitubercular inhibitor screened target gene Rv2498c and application thereof |
| CN104419710B (en) * | 2013-09-04 | 2017-06-16 | 上海市肺科医院 | A kind of resistance new gene of mycobacterium tuberculosis and its application |
| US10213766B2 (en) | 2015-09-18 | 2019-02-26 | Chevron Phillips Chemical Company Lp | Methods of preparing a catalyst |
-
2001
- 2001-10-12 GB GBGB0124593.5A patent/GB0124593D0/en not_active Ceased
-
2002
- 2002-10-14 AU AU2002337287A patent/AU2002337287A1/en not_active Abandoned
- 2002-10-14 WO PCT/GB2002/004647 patent/WO2003033530A2/en not_active Application Discontinuation
Non-Patent Citations (7)
| Title |
|---|
| COLER ET AL: "Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis", JOURNAL OF IMMUNOLOGY, vol. 166, May 2001 (2001-05-01), pages 6227 - 6235, XP002961490, ISSN: 0022-1767 * |
| DATABASE EMBL [online] 1 January 1998 (1998-01-01), "Acyl carrier protein", XP002250930, retrieved from EBI accession no. P71603 Database accession no. P71603 * |
| DATABASE EMBL [online] 1 June 1998 (1998-06-01), "Putative maturase homolog", XP002250931, retrieved from EBI accession no. O53616 Database accession no. O53616 * |
| IMBODEN ET AL: "Construction and characterization of a partial Myco- bacterium tuberculosis cDNA library of genes expressed at reduced oxygen tension", GENE, vol. 213, no. 1-2, 1998, pages 107 - 117, XP004125009, ISSN: 0378-1119 * |
| JAMES ET AL: "The physiology and pathogenicity of Mycobacterium tuberculosis grown under controlled conditions in a defined medium", JOURNAL OF APPLIED MICROBIOLOGY, vol. 88, no. 4, 2000, pages 669 - 677, XP000929200, ISSN: 1364-5072 * |
| PEREZ-GUZMAN: "Progressive age-related changes in pulmonary tuberculosis images and the effect of diabetes", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 162, 2000, pages 1738 - 1740, XP002250929 * |
| WONG ET AL: "Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry", INFECTION AND IMMUNITY, vol. 67, no. 1, 1999, pages 327 - 336, XP002250955 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003033530A2 (en) | 2003-04-24 |
| AU2002337287A1 (en) | 2003-04-28 |
| GB0124593D0 (en) | 2001-12-05 |
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