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WO2007011759A3 - Inhibitors of mitotic kinesin - Google Patents

Inhibitors of mitotic kinesin Download PDF

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Publication number
WO2007011759A3
WO2007011759A3 PCT/US2006/027449 US2006027449W WO2007011759A3 WO 2007011759 A3 WO2007011759 A3 WO 2007011759A3 US 2006027449 W US2006027449 W US 2006027449W WO 2007011759 A3 WO2007011759 A3 WO 2007011759A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
mitotic kinesin
kinesin
mitotic
ksp
Prior art date
Application number
PCT/US2006/027449
Other languages
French (fr)
Other versions
WO2007011759A2 (en
Inventor
Anthony B Pinkerton
Robert L Davis
Timothy Z Hoffman
Mark R Herbert
Original Assignee
Kalypsys Inc
Anthony B Pinkerton
Robert L Davis
Timothy Z Hoffman
Mark R Herbert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc, Anthony B Pinkerton, Robert L Davis, Timothy Z Hoffman, Mark R Herbert filed Critical Kalypsys Inc
Publication of WO2007011759A2 publication Critical patent/WO2007011759A2/en
Publication of WO2007011759A3 publication Critical patent/WO2007011759A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compounds and methods useful as inhibitors of KSP for the treatment or prevention of cellular proliferative diseases.
PCT/US2006/027449 2005-07-15 2006-07-13 Inhibitors of mitotic kinesin WO2007011759A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69952205P 2005-07-15 2005-07-15
US60/699,522 2005-07-15
US76024706P 2006-01-17 2006-01-17
US60/760,247 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007011759A2 WO2007011759A2 (en) 2007-01-25
WO2007011759A3 true WO2007011759A3 (en) 2007-04-12

Family

ID=37616876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027449 WO2007011759A2 (en) 2005-07-15 2006-07-13 Inhibitors of mitotic kinesin

Country Status (1)

Country Link
WO (1) WO2007011759A2 (en)

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GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
GB201314452D0 (en) 2013-08-13 2013-09-25 Ostara Biomedical Ltd Embryo implantation
GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
GB201517523D0 (en) 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
MA52422A (en) 2018-02-27 2021-01-06 Incyte Corp IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES AS A2A / A2B INHIBITORS
CN108484612B (en) * 2018-05-08 2020-04-17 郑州大学 Pyrimido 1,2, 4-triazole compound and preparation method and application thereof
WO2019222677A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
MA53097A (en) 2018-07-05 2021-05-12 Incyte Corp MERGED PYRAZINE DERIVATIVES AS A2A / A2B INHIBITORS
MX2021003158A (en) 2018-09-18 2021-07-16 Nikang Therapeutics Inc Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors.
TWI829857B (en) 2019-01-29 2024-01-21 美商英塞特公司 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
TWI883391B (en) 2020-02-18 2025-05-11 美商基利科學股份有限公司 Antiviral compounds
TWI874791B (en) 2020-02-18 2025-03-01 美商基利科學股份有限公司 Antiviral compounds
AR121356A1 (en) 2020-02-18 2022-05-11 Gilead Sciences Inc ANTIVIRAL COMPOUNDS
ES3028915T3 (en) 2021-04-16 2025-06-20 Gilead Sciences Inc Methods of preparing carbanucleosides using amides
CA3228162A1 (en) 2021-08-18 2023-02-23 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
CN119060061B (en) * 2024-08-26 2025-09-16 浙江师范大学 Application of a class of benzopyrimidine sulfide compounds as small molecule inhibitors of STING protein

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WO2004065392A1 (en) * 2003-01-24 2004-08-05 Smithkline Beecham Corporation Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands
WO2004087056A2 (en) * 2003-03-28 2004-10-14 Scios Inc. BI-CYCLIC PYRIMIDINE INHIBITORS OF TGFβ
WO2004108136A1 (en) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo `1 , 5-a!pyrimidines and their use in medicine
WO2005054246A2 (en) * 2003-12-04 2005-06-16 Merck Patent Gmbh Amine derivatives having a tyrosine-kinase-inhibiting effect
WO2006035061A1 (en) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hcv inhibiting bi-cyclic pyrimidines
WO2006078676A2 (en) * 2005-01-19 2006-07-27 Merck & Co., Inc. Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1567554A (en) * 1968-05-29 1969-05-16
US3910795A (en) * 1972-12-19 1975-10-07 Fuji Photo Film Co Ltd Fogged, direct positive silver halide emulsion sensitized with a nitrophenyl mercapto heterocyclic compound
JPS6157587A (en) * 1984-08-29 1986-03-24 Shionogi & Co Ltd Condensed heterocyclic derivative and antiulcerative
EP0728759A1 (en) * 1995-02-24 1996-08-28 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
WO2002002563A2 (en) * 2000-06-30 2002-01-10 Wyeth Substituted-triazolopyrimidines as anticancer agents
WO2003097615A1 (en) * 2002-05-17 2003-11-27 Scios, Inc. TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-β INHIBITORS
WO2004065392A1 (en) * 2003-01-24 2004-08-05 Smithkline Beecham Corporation Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands
WO2004087056A2 (en) * 2003-03-28 2004-10-14 Scios Inc. BI-CYCLIC PYRIMIDINE INHIBITORS OF TGFβ
WO2004108136A1 (en) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo `1 , 5-a!pyrimidines and their use in medicine
WO2005054246A2 (en) * 2003-12-04 2005-06-16 Merck Patent Gmbh Amine derivatives having a tyrosine-kinase-inhibiting effect
WO2006035061A1 (en) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hcv inhibiting bi-cyclic pyrimidines
WO2006078676A2 (en) * 2005-01-19 2006-07-27 Merck & Co., Inc. Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Non-Patent Citations (27)

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Title
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