WO2007011759A3 - Inhibiteurs de la kinesine mitotique - Google Patents
Inhibiteurs de la kinesine mitotique Download PDFInfo
- Publication number
- WO2007011759A3 WO2007011759A3 PCT/US2006/027449 US2006027449W WO2007011759A3 WO 2007011759 A3 WO2007011759 A3 WO 2007011759A3 US 2006027449 W US2006027449 W US 2006027449W WO 2007011759 A3 WO2007011759 A3 WO 2007011759A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhibitors
- mitotic kinesin
- kinesin
- mitotic
- ksp
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000010638 Kinesin Human genes 0.000 title 1
- 108010063296 Kinesin Proteins 0.000 title 1
- 230000000394 mitotic effect Effects 0.000 title 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention porte sur des composés et des procédés d'inhibition de la kinésine mitotique (KSP) pour traiter ou prévenir les maladies à prolifération cellulaire.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69952205P | 2005-07-15 | 2005-07-15 | |
US60/699,522 | 2005-07-15 | ||
US76024706P | 2006-01-17 | 2006-01-17 | |
US60/760,247 | 2006-01-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007011759A2 WO2007011759A2 (fr) | 2007-01-25 |
WO2007011759A3 true WO2007011759A3 (fr) | 2007-04-12 |
Family
ID=37616876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/027449 WO2007011759A2 (fr) | 2005-07-15 | 2006-07-13 | Inhibiteurs de la kinesine mitotique |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007011759A2 (fr) |
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GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
MA52422A (fr) | 2018-02-27 | 2021-01-06 | Incyte Corp | Imidazopyrimidines et triazolopyrimidines en tant qu'inhibiteurs a2a/a2b |
CN108484612B (zh) * | 2018-05-08 | 2020-04-17 | 郑州大学 | 嘧啶并1,2,4–三氮唑类化合物及其制备方法和应用 |
WO2019222677A1 (fr) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
MA53097A (fr) | 2018-07-05 | 2021-05-12 | Incyte Corp | Dérivés de pyrazine fusionnés en tant qu'inhibiteurs d'a2a/a2b |
MX2021003158A (es) | 2018-09-18 | 2021-07-16 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2. |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
AR121356A1 (es) | 2020-02-18 | 2022-05-11 | Gilead Sciences Inc | Compuestos antivirales |
ES3028915T3 (en) | 2021-04-16 | 2025-06-20 | Gilead Sciences Inc | Methods of preparing carbanucleosides using amides |
CA3228162A1 (fr) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Composes phospholipidiques et leurs procedes de production et d'utilisation |
CN119060061B (zh) * | 2024-08-26 | 2025-09-16 | 浙江师范大学 | 一类苯并嘧啶硫醚类化合物作为sting蛋白小分子抑制剂的应用 |
Citations (12)
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---|---|---|---|---|
FR1567554A (fr) * | 1968-05-29 | 1969-05-16 | ||
US3910795A (en) * | 1972-12-19 | 1975-10-07 | Fuji Photo Film Co Ltd | Fogged, direct positive silver halide emulsion sensitized with a nitrophenyl mercapto heterocyclic compound |
JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
EP0728759A1 (fr) * | 1995-02-24 | 1996-08-28 | Ono Pharmaceutical Co., Ltd. | Composés hétérocycliques |
WO2002002563A2 (fr) * | 2000-06-30 | 2002-01-10 | Wyeth | Triazolopyrimidines substitues comme agents anticancereux |
WO2003097615A1 (fr) * | 2002-05-17 | 2003-11-27 | Scios, Inc. | Traitement de troubles de fibro-proliferation au moyen d'inhibiteur de tgf-$g(b) |
WO2004065392A1 (fr) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5 |
WO2004087056A2 (fr) * | 2003-03-28 | 2004-10-14 | Scios Inc. | Inhibiteurs bi-cycliques a base de pyrimidine de tgf$g(b) |
WO2004108136A1 (fr) * | 2003-06-04 | 2004-12-16 | Vernalis (Cambridge) Limited | Triazolo`1,5-a!pyrimidines et leur utilisation en medecine |
WO2005054246A2 (fr) * | 2003-12-04 | 2005-06-16 | Merck Patent Gmbh | Derives d'amine |
WO2006035061A1 (fr) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Pyrimidines bicycliques inhibant le vhc |
WO2006078676A2 (fr) * | 2005-01-19 | 2006-07-27 | Merck & Co., Inc. | Pyrimidines bicycliques en tant qu'inhibiteurs de la dipeptidyl-peptidase-iv dans le traitement ou la prevention de diabetes |
-
2006
- 2006-07-13 WO PCT/US2006/027449 patent/WO2007011759A2/fr active Application Filing
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1567554A (fr) * | 1968-05-29 | 1969-05-16 | ||
US3910795A (en) * | 1972-12-19 | 1975-10-07 | Fuji Photo Film Co Ltd | Fogged, direct positive silver halide emulsion sensitized with a nitrophenyl mercapto heterocyclic compound |
JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
EP0728759A1 (fr) * | 1995-02-24 | 1996-08-28 | Ono Pharmaceutical Co., Ltd. | Composés hétérocycliques |
WO2002002563A2 (fr) * | 2000-06-30 | 2002-01-10 | Wyeth | Triazolopyrimidines substitues comme agents anticancereux |
WO2003097615A1 (fr) * | 2002-05-17 | 2003-11-27 | Scios, Inc. | Traitement de troubles de fibro-proliferation au moyen d'inhibiteur de tgf-$g(b) |
WO2004065392A1 (fr) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5 |
WO2004087056A2 (fr) * | 2003-03-28 | 2004-10-14 | Scios Inc. | Inhibiteurs bi-cycliques a base de pyrimidine de tgf$g(b) |
WO2004108136A1 (fr) * | 2003-06-04 | 2004-12-16 | Vernalis (Cambridge) Limited | Triazolo`1,5-a!pyrimidines et leur utilisation en medecine |
WO2005054246A2 (fr) * | 2003-12-04 | 2005-06-16 | Merck Patent Gmbh | Derives d'amine |
WO2006035061A1 (fr) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Pyrimidines bicycliques inhibant le vhc |
WO2006078676A2 (fr) * | 2005-01-19 | 2006-07-27 | Merck & Co., Inc. | Pyrimidines bicycliques en tant qu'inhibiteurs de la dipeptidyl-peptidase-iv dans le traitement ou la prevention de diabetes |
Non-Patent Citations (27)
Title |
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BAKHITE E A-G: "SYNTHESIS OF CERTAIN S-TRIAZOLOÄ1,5-AÜPYRIMIDINES STRUCTURALLY RELATED TO SOME CHEMOTHERAPEUTIC AGENTS", PHARMAZIE, DIE, GOVI VERLAG, ESCHBORN, DE, vol. 50, no. 1, 1995, pages 33 - 35, XP001182664, ISSN: 0031-7144 * |
COX C D ET AL: "Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 8, 15 April 2005 (2005-04-15), pages 2041 - 2045, XP004829169, ISSN: 0960-894X * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1988, ORLOV, V. D. ET AL: "Cyclocondensation of .alpha.,.beta.-unsaturated ketones with 3-amino-1,2,4-triazole", XP002417598, retrieved from STN Database accession no. 1989:75433 * |
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DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HIRAI, KENTARO ET AL: "Pyrazolo[1,5-a]- and [1,2,4]triazolo[1,5-a]pyrimidine derivatives", XP002417599, retrieved from STN Database accession no. 1986:626617 * |
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Also Published As
Publication number | Publication date |
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WO2007011759A2 (fr) | 2007-01-25 |
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