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WO2007011759A3 - Inhibiteurs de la kinesine mitotique - Google Patents

Inhibiteurs de la kinesine mitotique Download PDF

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Publication number
WO2007011759A3
WO2007011759A3 PCT/US2006/027449 US2006027449W WO2007011759A3 WO 2007011759 A3 WO2007011759 A3 WO 2007011759A3 US 2006027449 W US2006027449 W US 2006027449W WO 2007011759 A3 WO2007011759 A3 WO 2007011759A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
mitotic kinesin
kinesin
mitotic
ksp
Prior art date
Application number
PCT/US2006/027449
Other languages
English (en)
Other versions
WO2007011759A2 (fr
Inventor
Anthony B Pinkerton
Robert L Davis
Timothy Z Hoffman
Mark R Herbert
Original Assignee
Kalypsys Inc
Anthony B Pinkerton
Robert L Davis
Timothy Z Hoffman
Mark R Herbert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc, Anthony B Pinkerton, Robert L Davis, Timothy Z Hoffman, Mark R Herbert filed Critical Kalypsys Inc
Publication of WO2007011759A2 publication Critical patent/WO2007011759A2/fr
Publication of WO2007011759A3 publication Critical patent/WO2007011759A3/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des composés et des procédés d'inhibition de la kinésine mitotique (KSP) pour traiter ou prévenir les maladies à prolifération cellulaire.
PCT/US2006/027449 2005-07-15 2006-07-13 Inhibiteurs de la kinesine mitotique WO2007011759A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69952205P 2005-07-15 2005-07-15
US60/699,522 2005-07-15
US76024706P 2006-01-17 2006-01-17
US60/760,247 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007011759A2 WO2007011759A2 (fr) 2007-01-25
WO2007011759A3 true WO2007011759A3 (fr) 2007-04-12

Family

ID=37616876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027449 WO2007011759A2 (fr) 2005-07-15 2006-07-13 Inhibiteurs de la kinesine mitotique

Country Status (1)

Country Link
WO (1) WO2007011759A2 (fr)

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GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
GB201314452D0 (en) 2013-08-13 2013-09-25 Ostara Biomedical Ltd Embryo implantation
GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
GB201517523D0 (en) 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
MA52422A (fr) 2018-02-27 2021-01-06 Incyte Corp Imidazopyrimidines et triazolopyrimidines en tant qu'inhibiteurs a2a/a2b
CN108484612B (zh) * 2018-05-08 2020-04-17 郑州大学 嘧啶并1,2,4–三氮唑类化合物及其制备方法和应用
WO2019222677A1 (fr) 2018-05-18 2019-11-21 Incyte Corporation Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
MA53097A (fr) 2018-07-05 2021-05-12 Incyte Corp Dérivés de pyrazine fusionnés en tant qu'inhibiteurs d'a2a/a2b
MX2021003158A (es) 2018-09-18 2021-07-16 Nikang Therapeutics Inc Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2.
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
TWI874791B (zh) 2020-02-18 2025-03-01 美商基利科學股份有限公司 抗病毒化合物
AR121356A1 (es) 2020-02-18 2022-05-11 Gilead Sciences Inc Compuestos antivirales
ES3028915T3 (en) 2021-04-16 2025-06-20 Gilead Sciences Inc Methods of preparing carbanucleosides using amides
CA3228162A1 (fr) 2021-08-18 2023-02-23 Gilead Sciences, Inc. Composes phospholipidiques et leurs procedes de production et d'utilisation
CN119060061B (zh) * 2024-08-26 2025-09-16 浙江师范大学 一类苯并嘧啶硫醚类化合物作为sting蛋白小分子抑制剂的应用

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FR1567554A (fr) * 1968-05-29 1969-05-16
US3910795A (en) * 1972-12-19 1975-10-07 Fuji Photo Film Co Ltd Fogged, direct positive silver halide emulsion sensitized with a nitrophenyl mercapto heterocyclic compound
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
EP0728759A1 (fr) * 1995-02-24 1996-08-28 Ono Pharmaceutical Co., Ltd. Composés hétérocycliques
WO2002002563A2 (fr) * 2000-06-30 2002-01-10 Wyeth Triazolopyrimidines substitues comme agents anticancereux
WO2003097615A1 (fr) * 2002-05-17 2003-11-27 Scios, Inc. Traitement de troubles de fibro-proliferation au moyen d'inhibiteur de tgf-$g(b)
WO2004065392A1 (fr) * 2003-01-24 2004-08-05 Smithkline Beecham Corporation Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5
WO2004087056A2 (fr) * 2003-03-28 2004-10-14 Scios Inc. Inhibiteurs bi-cycliques a base de pyrimidine de tgf$g(b)
WO2004108136A1 (fr) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo`1,5-a!pyrimidines et leur utilisation en medecine
WO2005054246A2 (fr) * 2003-12-04 2005-06-16 Merck Patent Gmbh Derives d'amine
WO2006035061A1 (fr) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Pyrimidines bicycliques inhibant le vhc
WO2006078676A2 (fr) * 2005-01-19 2006-07-27 Merck & Co., Inc. Pyrimidines bicycliques en tant qu'inhibiteurs de la dipeptidyl-peptidase-iv dans le traitement ou la prevention de diabetes

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1567554A (fr) * 1968-05-29 1969-05-16
US3910795A (en) * 1972-12-19 1975-10-07 Fuji Photo Film Co Ltd Fogged, direct positive silver halide emulsion sensitized with a nitrophenyl mercapto heterocyclic compound
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
EP0728759A1 (fr) * 1995-02-24 1996-08-28 Ono Pharmaceutical Co., Ltd. Composés hétérocycliques
WO2002002563A2 (fr) * 2000-06-30 2002-01-10 Wyeth Triazolopyrimidines substitues comme agents anticancereux
WO2003097615A1 (fr) * 2002-05-17 2003-11-27 Scios, Inc. Traitement de troubles de fibro-proliferation au moyen d'inhibiteur de tgf-$g(b)
WO2004065392A1 (fr) * 2003-01-24 2004-08-05 Smithkline Beecham Corporation Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5
WO2004087056A2 (fr) * 2003-03-28 2004-10-14 Scios Inc. Inhibiteurs bi-cycliques a base de pyrimidine de tgf$g(b)
WO2004108136A1 (fr) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo`1,5-a!pyrimidines et leur utilisation en medecine
WO2005054246A2 (fr) * 2003-12-04 2005-06-16 Merck Patent Gmbh Derives d'amine
WO2006035061A1 (fr) * 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Pyrimidines bicycliques inhibant le vhc
WO2006078676A2 (fr) * 2005-01-19 2006-07-27 Merck & Co., Inc. Pyrimidines bicycliques en tant qu'inhibiteurs de la dipeptidyl-peptidase-iv dans le traitement ou la prevention de diabetes

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COX C D ET AL: "Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 8, 15 April 2005 (2005-04-15), pages 2041 - 2045, XP004829169, ISSN: 0960-894X *
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SUIKO M ET AL: "SYNTHESIS AND ANTITUMOR ACTIVITY OF 2-ALKANESULFINYL (OR ALKANESULFONYL)-7-METHYL-5H-1,3,4-THIADIAZOLO3,2-APYRIMIDIN-5-ONES", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, JAPAN SOC. FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEM, TOKYO, JP, vol. 41, no. 10, 1977, pages 2047 - 2053, XP001059128, ISSN: 0002-1369 *
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