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WO2008148967A3 - Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations - Google Patents

Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations Download PDF

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Publication number
WO2008148967A3
WO2008148967A3 PCT/FR2008/050728 FR2008050728W WO2008148967A3 WO 2008148967 A3 WO2008148967 A3 WO 2008148967A3 FR 2008050728 W FR2008050728 W FR 2008050728W WO 2008148967 A3 WO2008148967 A3 WO 2008148967A3
Authority
WO
WIPO (PCT)
Prior art keywords
topical
pharmaceutical
parenteral application
same
preparation methods
Prior art date
Application number
PCT/FR2008/050728
Other languages
English (en)
Other versions
WO2008148967A2 (fr
Inventor
Marc Moutet
Jean-Claude Yadan
Original Assignee
Galderma Res & Dev
Marc Moutet
Jean-Claude Yadan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev, Marc Moutet, Jean-Claude Yadan filed Critical Galderma Res & Dev
Priority to EP08805683A priority Critical patent/EP2155149A2/fr
Priority to US12/599,510 priority patent/US20100298259A1/en
Priority to CA002686558A priority patent/CA2686558A1/fr
Publication of WO2008148967A2 publication Critical patent/WO2008148967A2/fr
Publication of WO2008148967A3 publication Critical patent/WO2008148967A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne une composition pharmaceutique ou cosmétique pour application topique et/ou parentérale comprenant, dans un milieu physiologiquement acceptable, au moins un rétinoïde ou ses sels et dérivés, et au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques. L'invention s'applique en particulier en dermatologie humaine ou en chirurgie réparatrice.
PCT/FR2008/050728 2007-05-11 2008-04-22 Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations WO2008148967A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08805683A EP2155149A2 (fr) 2007-05-11 2008-04-22 Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
US12/599,510 US20100298259A1 (en) 2007-05-11 2008-04-22 Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same
CA002686558A CA2686558A1 (fr) 2007-05-11 2008-04-22 Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0755034 2007-05-11
FR0755034 2007-05-11

Publications (2)

Publication Number Publication Date
WO2008148967A2 WO2008148967A2 (fr) 2008-12-11
WO2008148967A3 true WO2008148967A3 (fr) 2009-02-19

Family

ID=38828706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/050728 WO2008148967A2 (fr) 2007-05-11 2008-04-22 Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations

Country Status (4)

Country Link
US (1) US20100298259A1 (fr)
EP (1) EP2155149A2 (fr)
CA (1) CA2686558A1 (fr)
WO (1) WO2008148967A2 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691279B2 (en) 2010-03-22 2014-04-08 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US8853184B2 (en) 2007-11-30 2014-10-07 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8921338B2 (en) 2010-03-12 2014-12-30 Allergan Industrie, Sas Fluid compositions for improving skin conditions
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US9228027B2 (en) 2008-09-02 2016-01-05 Allergan Holdings France S.A.S. Threads of Hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US9238013B2 (en) 2008-08-04 2016-01-19 Allergan Industrie, Sas Hyaluronic acid-based gels including lidocaine
US9265761B2 (en) 2007-11-16 2016-02-23 Allergan, Inc. Compositions and methods for treating purpura
US9333160B2 (en) 2010-01-13 2016-05-10 Allergan Industrie, Sas Heat stable hyaluronic acid compositions for dermatological use
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US10080767B2 (en) 2003-04-10 2018-09-25 Allergan Industrie Sas Injectable monophase hydrogels
US11844878B2 (en) 2011-09-06 2023-12-19 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
KR102312056B1 (ko) 2011-06-03 2021-10-12 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
ITMI20120027A1 (it) * 2012-01-12 2013-07-13 New Yemaya Internat Srl Composizione cosmetica avente azione rivitalizzante sull'epidermide
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
JP6656804B2 (ja) * 2014-11-26 2020-03-04 小林製薬株式会社 外用組成物
WO2016128783A1 (fr) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions et méthodes pour améliorer l'apparence de la peau
AU2016217792B2 (en) 2015-02-13 2020-07-02 Allergan Industrie, Sas Implants for sculpting, augmenting or correcting facial features such as the chin
FR3034989B1 (fr) * 2015-04-20 2017-05-19 Soc De Rech Cosmetique Sarl Compositions cosmetiques comprenant des oligomeres d'acide hyaluronique et des cellules vegetales dedifferenciees et elicitees de bougainvillier encapsulant un extrait de safran

Citations (10)

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EP0393904A2 (fr) * 1989-04-17 1990-10-24 Maxam, Inc. Véhicule hydradant pour l'application topique de l'acide vitamine A
WO1996010387A2 (fr) * 1994-09-30 1996-04-11 The Boots Company Plc Composition pour stimulant capillaire
WO1999062481A1 (fr) * 1998-05-29 1999-12-09 Guerlain S.A. Procede de traitement cosmetique pour lutter contre les effets du vieillissement cutane
US6024941A (en) * 1992-07-13 2000-02-15 Shiseido Company, Ltd. External skin treatment composition
KR20010001290A (ko) * 1999-06-03 2001-01-05 서경배 피부 주름의 개선 및 생성 억제 효과를 갖는 외용제 조성물
EP1153601A1 (fr) * 1999-02-17 2001-11-14 Kabushiki Kaisha Yakult Honsha Preparation pour la peau a usage externe
WO2004000242A1 (fr) * 2002-06-25 2003-12-31 Cosmeceutic Solutions Pty Ltd Compositions cosmetiques topiques
WO2004056877A1 (fr) * 2002-12-23 2004-07-08 Sintofarm S.P.A. Esters melanges d'acide hyaluronique comprenant des acides butyriques et hyaluroniques
WO2005039532A1 (fr) * 2003-10-17 2005-05-06 Fidia Farmaceutici S.P.A. Microemulsions de retinoide et compositions pharmaceutiques les contenant
WO2007074288A1 (fr) * 2005-12-21 2007-07-05 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations

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US4439614A (en) * 1982-09-22 1984-03-27 Sri International 5,6-Methano-5,6-dihydroretinoids
US4879114A (en) * 1985-12-20 1989-11-07 Angio-Medical Corporation Lipids from omentum and methods for cosmetic use
US5723139A (en) * 1996-09-27 1998-03-03 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Skin care compositions containing a polycyclic triterpene carboxylic acid and a retinoid
ATE245410T1 (de) * 1998-12-23 2003-08-15 Esparma Gmbh Mittel zum schutz der haut enthaltend hydrolysierte hyaluronsäure
ITMI20020756A1 (it) * 2002-04-09 2003-10-09 Sinclair Pharma S R L Composizioni farmaceutiche topiche per il trattamento delle dermatiti
US7491709B2 (en) * 2005-07-01 2009-02-17 Wayne Carey Treatment with hyaluronic acid

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* Cited by examiner, † Cited by third party
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EP0393904A2 (fr) * 1989-04-17 1990-10-24 Maxam, Inc. Véhicule hydradant pour l'application topique de l'acide vitamine A
US6024941A (en) * 1992-07-13 2000-02-15 Shiseido Company, Ltd. External skin treatment composition
WO1996010387A2 (fr) * 1994-09-30 1996-04-11 The Boots Company Plc Composition pour stimulant capillaire
WO1999062481A1 (fr) * 1998-05-29 1999-12-09 Guerlain S.A. Procede de traitement cosmetique pour lutter contre les effets du vieillissement cutane
EP1153601A1 (fr) * 1999-02-17 2001-11-14 Kabushiki Kaisha Yakult Honsha Preparation pour la peau a usage externe
KR20010001290A (ko) * 1999-06-03 2001-01-05 서경배 피부 주름의 개선 및 생성 억제 효과를 갖는 외용제 조성물
WO2004000242A1 (fr) * 2002-06-25 2003-12-31 Cosmeceutic Solutions Pty Ltd Compositions cosmetiques topiques
WO2004056877A1 (fr) * 2002-12-23 2004-07-08 Sintofarm S.P.A. Esters melanges d'acide hyaluronique comprenant des acides butyriques et hyaluroniques
WO2005039532A1 (fr) * 2003-10-17 2005-05-06 Fidia Farmaceutici S.P.A. Microemulsions de retinoide et compositions pharmaceutiques les contenant
WO2007074288A1 (fr) * 2005-12-21 2007-07-05 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations

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DATABASE WPI Week 200146, Derwent World Patents Index; AN 2001-430654, XP002463330 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10080767B2 (en) 2003-04-10 2018-09-25 Allergan Industrie Sas Injectable monophase hydrogels
US9265761B2 (en) 2007-11-16 2016-02-23 Allergan, Inc. Compositions and methods for treating purpura
US8853184B2 (en) 2007-11-30 2014-10-07 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US9358322B2 (en) 2008-08-04 2016-06-07 Allergan Industrie Sas Hyaluronic acid-based gels including lidocaine
US10328180B2 (en) 2008-08-04 2019-06-25 Allergan Industrie, S.A.S. Hyaluronic acid-based gels including lidocaine
US9238013B2 (en) 2008-08-04 2016-01-19 Allergan Industrie, Sas Hyaluronic acid-based gels including lidocaine
US9228027B2 (en) 2008-09-02 2016-01-05 Allergan Holdings France S.A.S. Threads of Hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US10806821B2 (en) 2010-01-13 2020-10-20 Allergan Industrie, Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US9333160B2 (en) 2010-01-13 2016-05-10 Allergan Industrie, Sas Heat stable hyaluronic acid compositions for dermatological use
US9125840B2 (en) 2010-03-12 2015-09-08 Allergan Industrie Sas Methods for improving skin conditions
US9585821B2 (en) 2010-03-12 2017-03-07 Allergan Industrie Sas Methods for making compositions for improving skin conditions
US8921338B2 (en) 2010-03-12 2014-12-30 Allergan Industrie, Sas Fluid compositions for improving skin conditions
US9012517B2 (en) 2010-03-22 2015-04-21 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US8691279B2 (en) 2010-03-22 2014-04-08 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US11844878B2 (en) 2011-09-06 2023-12-19 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation

Also Published As

Publication number Publication date
EP2155149A2 (fr) 2010-02-24
CA2686558A1 (fr) 2008-12-11
WO2008148967A2 (fr) 2008-12-11
US20100298259A1 (en) 2010-11-25

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