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WO2008153040A1 - Microchip and analysis method using the same - Google Patents

Microchip and analysis method using the same Download PDF

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Publication number
WO2008153040A1
WO2008153040A1 PCT/JP2008/060648 JP2008060648W WO2008153040A1 WO 2008153040 A1 WO2008153040 A1 WO 2008153040A1 JP 2008060648 W JP2008060648 W JP 2008060648W WO 2008153040 A1 WO2008153040 A1 WO 2008153040A1
Authority
WO
WIPO (PCT)
Prior art keywords
microchip
sample
section
same
introducing
Prior art date
Application number
PCT/JP2008/060648
Other languages
French (fr)
Japanese (ja)
Inventor
Hisao Kawaura
Original Assignee
Nec Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nec Corporation filed Critical Nec Corporation
Publication of WO2008153040A1 publication Critical patent/WO2008153040A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Provided is a microchip which separates a sample in a short time with excellent repeatability and high measurement accuracy. The microchip is provided with a substrate (102), and a channel formed on the surface of the substrate (102) for passing a sample solution. The channel is provided with an analysis section (103) for separating the sample solution, and a sample introducing section (104) adjacent to the analysis section (103) for introducing the sample solution. The surface of the sample introducing section (104) includes a hydrophobic surface (106) and a hydrophilic region, and the hydrophilic region forms a hydrophilic surface (105) by being brought into contact with the surface of the analysis section (103).
PCT/JP2008/060648 2007-06-14 2008-06-11 Microchip and analysis method using the same WO2008153040A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-157848 2007-06-14
JP2007157848A JP2008309642A (en) 2007-06-14 2007-06-14 Microchip and analytical method using the same

Publications (1)

Publication Number Publication Date
WO2008153040A1 true WO2008153040A1 (en) 2008-12-18

Family

ID=40129645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060648 WO2008153040A1 (en) 2007-06-14 2008-06-11 Microchip and analysis method using the same

Country Status (2)

Country Link
JP (1) JP2008309642A (en)
WO (1) WO2008153040A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014173935A (en) * 2013-03-07 2014-09-22 Toshiba Corp Semiconductor micro-analysis chip and manufacturing method thereof
JPWO2014045482A1 (en) * 2012-09-19 2016-08-18 日本電気株式会社 Analysis chip and analyzer
JP2016212090A (en) * 2015-05-13 2016-12-15 アークレイ株式会社 Analysis tools and analysis systems

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5948248B2 (en) * 2010-11-01 2016-07-06 コニカミノルタ株式会社 Microchip and method for manufacturing microchip
JP2015222177A (en) * 2012-09-19 2015-12-10 シャープ株式会社 Chip, analyzer and analysis system
JP7276798B2 (en) * 2017-09-22 2023-05-18 国立研究開発法人理化学研究所 Microfluidic device and manufacturing method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004069430A (en) * 2002-08-05 2004-03-04 Mitsubishi Kagaku Iatron Inc Electrophoresis chip, method for producing the same, and method for separating substances
JP2004077305A (en) * 2002-08-19 2004-03-11 Nec Corp Detector
WO2005124332A1 (en) * 2004-06-15 2005-12-29 Nec Corporation Electrophoretic chip, electrophoretic device and electrophoresis method
JP2006250622A (en) * 2005-03-09 2006-09-21 Shimadzu Corp Electrophoresis method using capillary plate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004069430A (en) * 2002-08-05 2004-03-04 Mitsubishi Kagaku Iatron Inc Electrophoresis chip, method for producing the same, and method for separating substances
JP2004077305A (en) * 2002-08-19 2004-03-11 Nec Corp Detector
WO2005124332A1 (en) * 2004-06-15 2005-12-29 Nec Corporation Electrophoretic chip, electrophoretic device and electrophoresis method
JP2006250622A (en) * 2005-03-09 2006-09-21 Shimadzu Corp Electrophoresis method using capillary plate

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2014045482A1 (en) * 2012-09-19 2016-08-18 日本電気株式会社 Analysis chip and analyzer
JP2014173935A (en) * 2013-03-07 2014-09-22 Toshiba Corp Semiconductor micro-analysis chip and manufacturing method thereof
JP2016212090A (en) * 2015-05-13 2016-12-15 アークレイ株式会社 Analysis tools and analysis systems
JP2018072350A (en) * 2015-05-13 2018-05-10 アークレイ株式会社 Analysis system

Also Published As

Publication number Publication date
JP2008309642A (en) 2008-12-25

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