[go: up one dir, main page]

WO2008153040A1 - Micropuce et procédé d'analyse l'utilisant - Google Patents

Micropuce et procédé d'analyse l'utilisant Download PDF

Info

Publication number
WO2008153040A1
WO2008153040A1 PCT/JP2008/060648 JP2008060648W WO2008153040A1 WO 2008153040 A1 WO2008153040 A1 WO 2008153040A1 JP 2008060648 W JP2008060648 W JP 2008060648W WO 2008153040 A1 WO2008153040 A1 WO 2008153040A1
Authority
WO
WIPO (PCT)
Prior art keywords
microchip
sample
section
same
introducing
Prior art date
Application number
PCT/JP2008/060648
Other languages
English (en)
Japanese (ja)
Inventor
Hisao Kawaura
Original Assignee
Nec Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nec Corporation filed Critical Nec Corporation
Publication of WO2008153040A1 publication Critical patent/WO2008153040A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne une micropuce qui sépare un échantillon en un court temps avec une excellente capacité de répétition et une précision de mesure élevée. La micropuce comporte un substrat (102), et un canal formé sur la surface du substrat (102) pour faire passer une solution d'échantillon. Le canal comporte une section d'analyse (103) pour séparer la solution d'échantillon, et une section d'introduction d'échantillon (104) adjacente à la section d'analyse (103) pour introduire la solution d'échantillon. La surface de la section d'introduction d'échantillon (104) comprend une surface hydrophobe (106) et une région d'hydrophile, et la région hydrophile forme une surface hydrophile (105) en étant amenée en contact avec la surface de la section d'analyse (103).
PCT/JP2008/060648 2007-06-14 2008-06-11 Micropuce et procédé d'analyse l'utilisant WO2008153040A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007157848A JP2008309642A (ja) 2007-06-14 2007-06-14 マイクロチップおよびこれを用いた分析方法
JP2007-157848 2007-06-14

Publications (1)

Publication Number Publication Date
WO2008153040A1 true WO2008153040A1 (fr) 2008-12-18

Family

ID=40129645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060648 WO2008153040A1 (fr) 2007-06-14 2008-06-11 Micropuce et procédé d'analyse l'utilisant

Country Status (2)

Country Link
JP (1) JP2008309642A (fr)
WO (1) WO2008153040A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014173935A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
JPWO2014045482A1 (ja) * 2012-09-19 2016-08-18 日本電気株式会社 分析チップ、及び分析装置
JP2016212090A (ja) * 2015-05-13 2016-12-15 アークレイ株式会社 分析用具および分析システム

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012060186A1 (fr) * 2010-11-01 2012-05-10 コニカミノルタオプト株式会社 Micropuce et procédé de fabrication d'une micropuce
JP2015222177A (ja) * 2012-09-19 2015-12-10 シャープ株式会社 チップ、分析装置および分析システム
JP7276798B2 (ja) * 2017-09-22 2023-05-18 国立研究開発法人理化学研究所 マイクロ流路デバイス及びその製造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004069430A (ja) * 2002-08-05 2004-03-04 Mitsubishi Kagaku Iatron Inc 電気泳動用チップ、その製造方法、及び物質の分離方法
JP2004077305A (ja) * 2002-08-19 2004-03-11 Nec Corp 検出装置
WO2005124332A1 (fr) * 2004-06-15 2005-12-29 Nec Corporation Puce électrophorétique; dispositf électrophorétique et procédé d'électrophorèse
JP2006250622A (ja) * 2005-03-09 2006-09-21 Shimadzu Corp キャピラリープレートを用いた電気泳動方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004069430A (ja) * 2002-08-05 2004-03-04 Mitsubishi Kagaku Iatron Inc 電気泳動用チップ、その製造方法、及び物質の分離方法
JP2004077305A (ja) * 2002-08-19 2004-03-11 Nec Corp 検出装置
WO2005124332A1 (fr) * 2004-06-15 2005-12-29 Nec Corporation Puce électrophorétique; dispositf électrophorétique et procédé d'électrophorèse
JP2006250622A (ja) * 2005-03-09 2006-09-21 Shimadzu Corp キャピラリープレートを用いた電気泳動方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2014045482A1 (ja) * 2012-09-19 2016-08-18 日本電気株式会社 分析チップ、及び分析装置
JP2014173935A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
JP2016212090A (ja) * 2015-05-13 2016-12-15 アークレイ株式会社 分析用具および分析システム
JP2018072350A (ja) * 2015-05-13 2018-05-10 アークレイ株式会社 分析システム

Also Published As

Publication number Publication date
JP2008309642A (ja) 2008-12-25

Similar Documents

Publication Publication Date Title
WO2010091410A3 (fr) Perfectionnements apportés ou se rapportant à des performances
WO2008153040A1 (fr) Micropuce et procédé d'analyse l'utilisant
WO2007121263A3 (fr) Structure destinée à introduire plusieurs solutions, dispositif microfluidique comportant une telle structure et procédé destiné à introduire une solution
WO2008024835A3 (fr) dispositifs microfluidiqueS et procédés facilitant un débit élevé, techniques de détection et de séparation sur puce
WO2009111431A3 (fr) Processus d’interface avec un dispositif microfluidique numérique
WO2007041692A3 (fr) Detection microfluidique d'analytes
WO2008034833A3 (fr) appareil destiné à recevoir des échantillons biologiques et procédé pour leur dissection au laser
WO2006113527A3 (fr) Dispositifs et systemes de chromatographie integree pour controler des substances a analyser en temps reel et procedes pour les produire
WO2008013801A3 (fr) Revêtements pour capillaires capables de capturer des analytes
WO2007047908A3 (fr) Appareil et procede permettant d'effectuer des decomptes dans un echantillon de fluide biologique
WO2008039946A3 (fr) Dispositif de mesure intégré pour l'analyse d'échantillons biologiques
WO2005118863A3 (fr) Materiaux microporeux, procedes de fabrication et articles associes
WO2007078635A3 (fr) Procede de detection de petites molecules adherant a des proteines par diffusion raman exaltee de surface (sers)
WO2008139867A1 (fr) Puce d'analyse et appareil d'analyse
WO2009051821A3 (fr) Dispositifs de préparation et d'analyse d'échantillons
DE602006011756D1 (de) Komplexformierungs- und -trennungsverfahren
WO2006116616A3 (fr) Systemes et procedes de detection multiple d'analytes
WO2008097700A3 (fr) Analyseur chimique pour contrôle de procédé industriel
ATE493932T1 (de) Analytisches hilfsmittel
WO2009134944A3 (fr) Procédés de détermination de l'état de santé d'un individu
WO2004061414A3 (fr) Procede et dispositif permettant de repartir des echantillons dans les canaux multiples d'un dispositif microfluidique
WO2006089027A3 (fr) Kit d'analyse a ecoulement lateral et procede de detection d'analyte
WO2008135862A3 (fr) Dispositifs et procédés pour détecter des analysats
WO2009121032A3 (fr) Dispositifs de préparation d’échantillons et procédés de traitement d’analytes
WO2004094994A3 (fr) Dispositifs microfluidiques et procédés

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08765427

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08765427

Country of ref document: EP

Kind code of ref document: A1