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WO2009004999A8 - シームレスカプセル - Google Patents

シームレスカプセル Download PDF

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Publication number
WO2009004999A8
WO2009004999A8 PCT/JP2008/061721 JP2008061721W WO2009004999A8 WO 2009004999 A8 WO2009004999 A8 WO 2009004999A8 JP 2008061721 W JP2008061721 W JP 2008061721W WO 2009004999 A8 WO2009004999 A8 WO 2009004999A8
Authority
WO
WIPO (PCT)
Prior art keywords
seamless capsule
interfacial tension
tension regulator
gelation accelerator
capsule
Prior art date
Application number
PCT/JP2008/061721
Other languages
English (en)
French (fr)
Other versions
WO2009004999A1 (ja
Inventor
Tomohiro Yoshinari
Yoshihiro Uchiyama
Original Assignee
Takeda Pharmaceutical
Tomohiro Yoshinari
Yoshihiro Uchiyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40226045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009004999(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical, Tomohiro Yoshinari, Yoshihiro Uchiyama filed Critical Takeda Pharmaceutical
Priority to AU2008272135A priority Critical patent/AU2008272135B2/en
Priority to US12/452,374 priority patent/US20100119598A1/en
Priority to ES08790686T priority patent/ES2748934T3/es
Priority to JP2009521608A priority patent/JP5047285B2/ja
Priority to CN2008801051658A priority patent/CN101801416B/zh
Priority to NZ582576A priority patent/NZ582576A/en
Priority to EP08790686.3A priority patent/EP2172225B1/en
Publication of WO2009004999A1 publication Critical patent/WO2009004999A1/ja
Publication of WO2009004999A8 publication Critical patent/WO2009004999A8/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　本発明は、界面張力調整剤やゲル化促進剤を使用しないシームレスカプセルの提供を目的とする。本発明において、ゼラチンおよび可塑剤を含有し、かつ、界面張力調整剤またはゲル化促進剤を含有しないシェル組成物により形成されたシェル、および、界面張力調整剤またはゲル化促進剤を含有しないカプセル内容物からなるシームレスカプセルを提供する。
PCT/JP2008/061721 2007-06-29 2008-06-27 シームレスカプセル WO2009004999A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2008272135A AU2008272135B2 (en) 2007-06-29 2008-06-27 Seamless capsule
US12/452,374 US20100119598A1 (en) 2007-06-29 2008-06-27 Seamless capsule
ES08790686T ES2748934T3 (es) 2007-06-29 2008-06-27 Cápsula sin costura
JP2009521608A JP5047285B2 (ja) 2007-06-29 2008-06-27 シームレスカプセル
CN2008801051658A CN101801416B (zh) 2007-06-29 2008-06-27 无缝胶囊
NZ582576A NZ582576A (en) 2007-06-29 2008-06-27 Seamless capsule comprising gelatin and a plasticizer
EP08790686.3A EP2172225B1 (en) 2007-06-29 2008-06-27 Seamless capsule

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-173198 2007-06-29
JP2007173198 2007-06-29

Publications (2)

Publication Number Publication Date
WO2009004999A1 WO2009004999A1 (ja) 2009-01-08
WO2009004999A8 true WO2009004999A8 (ja) 2009-04-09

Family

ID=40226045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061721 WO2009004999A1 (ja) 2007-06-29 2008-06-27 シームレスカプセル

Country Status (11)

Country Link
US (1) US20100119598A1 (ja)
EP (1) EP2172225B1 (ja)
JP (1) JP5047285B2 (ja)
KR (1) KR20100039362A (ja)
CN (2) CN101801416B (ja)
AU (1) AU2008272135B2 (ja)
ES (1) ES2748934T3 (ja)
MY (1) MY157882A (ja)
NZ (1) NZ582576A (ja)
TW (1) TW200911358A (ja)
WO (1) WO2009004999A1 (ja)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100111292A (ko) * 2008-01-10 2010-10-14 다케다 야쿠힌 고교 가부시키가이샤 캡슐 제제
EP3187182B1 (en) 2008-09-02 2021-03-03 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
DK2596786T3 (da) 2009-02-10 2020-02-24 Amarin Pharmaceuticals Ie Ltd Anvendelse af eicosapentaensyreethylester til behandling af hypertriglyceridæmi
MY205872A (en) 2009-04-29 2024-11-18 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising omega-3 fatty acids
RU2538691C2 (ru) * 2009-04-29 2015-01-10 Амарин Фарма, Инк. Стабильные фармацевтические композиции и способы их применения
LT3318255T (lt) * 2009-06-15 2021-05-25 Amarin Pharmaceuticals Ireland Limited Kompozicijos ir būdai, skirti insulto gydymui pacientui kartu su statinų terapija
JP5421674B2 (ja) * 2009-07-01 2014-02-19 株式会社ファンケル ソフトカプセル用乳化組成物及びソフトカプセル剤
BR122019016628B8 (pt) 2009-09-23 2021-07-27 Amarin Corp Plc uso de uma composição compreendendo um derivado de hidróxi de atorvastatina ou sal farmaceuticamente aceitável do mesmo e um óleo compreendendo etil eicosapentaenoato ou etil docosahexaenoato para a fabricação de um medicamento para o tratamento de uma doença cardiovascular
EP2646013A4 (en) 2010-11-29 2014-03-26 Amarin Pharma Inc Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
JP5876695B2 (ja) 2011-09-29 2016-03-02 森下仁丹株式会社 シームレスカプセルおよびその製造方法
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd METHODS OF TREATING HYPERTRIGLYCERIDEMIA
ES2891473T3 (es) 2012-01-06 2022-01-28 Amarin Pharmaceuticals Ie Ltd Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto
CN104582698A (zh) 2012-06-29 2015-04-29 阿玛林制药爱尔兰有限公司 在接受抑制素治疗的受试者中降低心血管事件风险的方法
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
JP5581446B1 (ja) 2013-04-15 2014-08-27 三生医薬株式会社 崩壊可能なカプセル及びその製造方法並びに喫煙器具
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN106455633B (zh) * 2014-01-31 2020-07-17 森下仁丹株式会社 用于反刍动物的经口给予药剂和含有该药剂的反刍动物用饲料
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
JP6884369B2 (ja) * 2016-12-28 2021-06-09 三生医薬株式会社 シームレスカプセル
TW201900160A (zh) 2017-05-19 2019-01-01 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
DK4056176T3 (da) 2018-09-24 2024-05-06 Amarin Pharmaceuticals Ie Ltd Fremgangsmåde til at reducere risikoen af kardiovaskulære hændelser hos et individ
CN111040021B (zh) * 2018-10-12 2023-06-02 浙江道尔生物科技有限公司 一种改善生物活性蛋白性质的载体蛋白
JP6603817B1 (ja) 2019-01-18 2019-11-06 三生医薬株式会社 シ−ムレスカプセルならびにこれを含むフィルターおよび喫煙器具
KR20200105068A (ko) 2019-02-28 2020-09-07 우석대학교 산학협력단 오일을 함유하는 심리스 캡슐의 제조방법
WO2021097120A1 (en) 2019-11-12 2021-05-20 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter
KR102204696B1 (ko) * 2019-12-10 2021-01-19 한국 한의학 연구원 1-모노에이코사펜타에노인을 유효성분으로 함유하는 주름개선용 조성물
EP4129275A4 (en) 2020-03-30 2023-11-22 Sunsho Pharmaceutical Co., Ltd. COMPOSITION CONTAINING A MENTHOL
CN116507220A (zh) 2020-11-06 2023-07-28 学校法人近畿大学 血管疾病治疗用组合物、血管疾病预防用组合物、高血压治疗用组合物和高血压预防用组合物
JP6913976B1 (ja) * 2020-11-13 2021-08-04 東洋カプセル株式会社 シームレスカプセル及びその製造方法
WO2022225896A1 (en) 2021-04-21 2022-10-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure
US20250120427A1 (en) 2021-09-14 2025-04-17 Sunsho Pharmaceutical Co., Ltd. Caryophyllene-containing composition
US20240382434A1 (en) 2021-09-14 2024-11-21 Sunsho Pharmaceutical Co., Ltd. Caryophyllene-containing composition
KR102864596B1 (ko) 2022-04-25 2025-09-26 유엠에스엔지니어링 주식회사 오메가 3 심리스 연질캡슐 제조방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819110D0 (en) * 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production
JP2806564B2 (ja) * 1989-07-20 1998-09-30 森下仁丹株式会社 親水性物質を内容物とするシームレスカプセルおよびその製法
JPH0412083A (ja) * 1990-04-27 1992-01-16 Osaka Titanium Co Ltd シリコン単結晶製造方法
JP3159724B2 (ja) 1991-04-19 2001-04-23 フロイント産業株式会社 シームレスカプセル製造方法および装置
JPH0826976A (ja) * 1994-07-21 1996-01-30 Freunt Ind Co Ltd 食品状医薬品
US5650232A (en) * 1994-10-07 1997-07-22 Warner-Lambert Company Method for making seamless capsules
JP3759986B2 (ja) * 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
ATE305810T1 (de) * 2000-05-22 2005-10-15 Pro Aparts Investimentos E Con Fettsäure enthaltende pharmazeutische zusammensetzung die wenigstens 80 gew. epa und dha enthält
ATE340566T1 (de) * 2002-12-05 2006-10-15 Symrise Gmbh & Co Kg Nahtlose gefüllte kapseln
AU2003288606A1 (en) * 2002-12-20 2004-07-14 Pronova Biocare As Use of a fatty acid composition for treatment of male infertility
JP2004262774A (ja) * 2003-02-20 2004-09-24 Freunt Ind Co Ltd シームレスカプセル
GB0403247D0 (en) * 2004-02-13 2004-03-17 Tillotts Pharma Ag A pharmaceutical composition
WO2005077521A1 (en) * 2004-02-17 2005-08-25 Symrise Gmbh & Co. Kg Coated sherical seamless filled capsules
WO2008012329A2 (en) * 2006-07-28 2008-01-31 V. Mane Fils Seamless capsules containing high amounts of polyunsaturated fatty acids and a flavouring component

Also Published As

Publication number Publication date
EP2172225A4 (en) 2011-04-27
EP2172225A1 (en) 2010-04-07
AU2008272135B2 (en) 2013-10-31
TW200911358A (en) 2009-03-16
NZ582576A (en) 2012-05-25
CN102552213A (zh) 2012-07-11
AU2008272135A1 (en) 2009-01-08
MY157882A (en) 2016-07-29
US20100119598A1 (en) 2010-05-13
CN101801416A (zh) 2010-08-11
KR20100039362A (ko) 2010-04-15
JP5047285B2 (ja) 2012-10-10
EP2172225B1 (en) 2019-08-07
EP2172225A8 (en) 2011-06-29
ES2748934T3 (es) 2020-03-18
CN101801416B (zh) 2012-10-24
JPWO2009004999A1 (ja) 2010-08-26
WO2009004999A1 (ja) 2009-01-08

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