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WO2011095990A3 - Procédé pour la purification de prostaglandines et analogues de celles-ci - Google Patents

Procédé pour la purification de prostaglandines et analogues de celles-ci Download PDF

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Publication number
WO2011095990A3
WO2011095990A3 PCT/IN2011/000076 IN2011000076W WO2011095990A3 WO 2011095990 A3 WO2011095990 A3 WO 2011095990A3 IN 2011000076 W IN2011000076 W IN 2011000076W WO 2011095990 A3 WO2011095990 A3 WO 2011095990A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostaglandins
analogues
purification
formula
prostaglandin derivative
Prior art date
Application number
PCT/IN2011/000076
Other languages
English (en)
Other versions
WO2011095990A2 (fr
Inventor
Mohan Anand Chandavarkar
Ramakrishnan Ramachandran Iyer
Vikas Vasant Nawathye
Gajanan Jalindar Chavan
Sandeep Laxman Nawale
Original Assignee
Fdc Limited
Chachad, Kalpesh, Chintamani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fdc Limited, Chachad, Kalpesh, Chintamani filed Critical Fdc Limited
Publication of WO2011095990A2 publication Critical patent/WO2011095990A2/fr
Publication of WO2011095990A3 publication Critical patent/WO2011095990A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé pour la purification de prostaglandines de formule (1) en isomère énantiomériquement pur de formule (2) par CLHP préparative en phase inverse, et la conversion dudit isomère en dérivé de prostaglandine de formule (3). Le dérivé de prostaglandine dans cette invention est apparenté à des analogues de PGF2α.
PCT/IN2011/000076 2010-02-03 2011-02-02 Procédé pour la purification de prostaglandines et analogues de celles-ci WO2011095990A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN283/MUM/2010 2010-02-03
IN283MU2010 2010-02-03

Publications (2)

Publication Number Publication Date
WO2011095990A2 WO2011095990A2 (fr) 2011-08-11
WO2011095990A3 true WO2011095990A3 (fr) 2012-01-12

Family

ID=44247901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000076 WO2011095990A2 (fr) 2010-02-03 2011-02-02 Procédé pour la purification de prostaglandines et analogues de celles-ci

Country Status (1)

Country Link
WO (1) WO2011095990A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103543216A (zh) * 2012-07-17 2014-01-29 上海信谊药厂有限公司 拉坦前列素滴眼液中杂质测定的方法
TWI435752B (zh) * 2012-08-15 2014-05-01 Everlight Chem Ind Corp 使用製備型高效液相層析儀純化含氟之前列腺素之方法
CN104297352B (zh) * 2013-07-16 2017-11-07 天津金耀集团有限公司 一种曲伏前列素含量及有关物质的分析方法
US9115109B2 (en) * 2013-08-15 2015-08-25 Chirogate International Inc. Processes and intermediates for the preparations of isomer free prostaglandins
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
CN112209863A (zh) * 2020-07-07 2021-01-12 浙江尖峰药业有限公司 一种他氟前列素规模化制备的方法
CN116583500A (zh) * 2020-12-23 2023-08-11 协和医药化工股份有限公司 几何异构体的分离方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155973A1 (en) * 2005-12-30 2007-07-05 Everlight Usa, Inc. Novel intermediate compound for the preparation of prostaglandin F analogue
WO2008081191A1 (fr) * 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Procédé amélioré pour la réaction de wittig dans la préparation de carboprost

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962312A (en) 1972-09-21 1976-06-08 Ono Pharmaceutical Company 9,11,15-Trihydroxy prost-5-enoic acid analogues
WO1990002553A1 (fr) 1988-09-06 1990-03-22 Pharmacia Ab Derives de prostaglandine servant au traitement des glaucomes ou de l'hypertension oculaire
US7166730B2 (en) 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
PL366372A1 (en) 2001-07-17 2005-01-24 Pharmacia & Upjohn Company Process and intermediates to prepare latanoprost
PL212658B1 (pl) 2005-04-18 2012-11-30 Inst Farmaceutyczny Sposób otrzymywania pochodnych 13,14-dihydro-PGF<sub>2</sub><sub>α</sub>

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155973A1 (en) * 2005-12-30 2007-07-05 Everlight Usa, Inc. Novel intermediate compound for the preparation of prostaglandin F analogue
WO2008081191A1 (fr) * 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Procédé amélioré pour la réaction de wittig dans la préparation de carboprost

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GUZZETTA ANDREW: "Reverse Phase HPLC Basics for LC/MS", INTERNET CITATION, 22 July 2001 (2001-07-22), pages 1 - 9, XP002556091, Retrieved from the Internet <URL:http://ionsource.com/tutorial/chromatography/rphplc.htm> [retrieved on 20091118] *

Also Published As

Publication number Publication date
WO2011095990A2 (fr) 2011-08-11

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