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WO2018123063A1 - Dispositif de thérapie par particules - Google Patents

Dispositif de thérapie par particules Download PDF

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Publication number
WO2018123063A1
WO2018123063A1 PCT/JP2016/089207 JP2016089207W WO2018123063A1 WO 2018123063 A1 WO2018123063 A1 WO 2018123063A1 JP 2016089207 W JP2016089207 W JP 2016089207W WO 2018123063 A1 WO2018123063 A1 WO 2018123063A1
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WO
WIPO (PCT)
Prior art keywords
magnetic field
field strength
energy
particle beam
deflection electromagnet
Prior art date
Application number
PCT/JP2016/089207
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English (en)
Japanese (ja)
Inventor
周平 小田原
雅 片寄
Original Assignee
三菱電機株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 三菱電機株式会社 filed Critical 三菱電機株式会社
Priority to PCT/JP2016/089207 priority Critical patent/WO2018123063A1/fr
Priority to TW106121794A priority patent/TW201822836A/zh
Publication of WO2018123063A1 publication Critical patent/WO2018123063A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a particle beam treatment apparatus for performing cancer treatment or the like by irradiating a particle beam.
  • Patent Document 1 discloses a medical electronic accelerator that is not affected by fluctuations in magnetic flux density due to hysteresis, because the magnetic flux density of an electromagnet is always saturated at every set-up time and then fixed to a desired value.
  • JP-A-3-236862 page 2, lower right column, line 18 to page 3, upper left column, first line, FIG. 3
  • the method of initialization as in Patent Document 1 has a problem that initialization takes time.
  • the relationship between the magnetic field strength and the excitation current is not uniquely determined, and it is difficult to ensure the accuracy of the magnetic field strength.
  • the deviation from the target magnetic field strength differs depending on the starting point, magnitude, and increase / decrease direction of the magnetic field strength change, it is necessary to create and accumulate a huge amount of setting data for each magnetic field strength change pattern. There was a problem that this led to a large cost increase.
  • the present invention has been made to solve the above-described problems, and an object of the present invention is to provide a particle beam therapy system capable of shortening the setting time and realizing high-precision beam irradiation.
  • the ion beam is deflected, and the target magnetic field strength is lower than the first magnetic field strength from the first magnetic field strength higher than the target magnetic field strength by the main coil.
  • a deflection electromagnet for supplying an irradiation system with an ion beam corrected to the target magnetic field intensity by a correction coil sharing the iron core with the main coil after adjusting to a second magnetic field intensity higher by a predetermined amount than It is a feature.
  • the present invention by limiting the excitation of the correction coil sharing the iron core to the direction to cancel the excitation of the main coil, the same beam state can be maintained even after the energy change, and the setting time can be shortened, High-precision beam irradiation can be realized.
  • FIG. 1 is a diagram of a deflecting electromagnet which is a main configuration of a particle beam therapy system 100 according to Embodiment 1 of the present invention
  • FIG. 1 (a) shows a side view
  • FIG. 1 (b) shows FIG.
  • the arrow sectional view in the AA line of a) is shown.
  • FIG. 2 is a bird's-eye view of a schematic configuration of the entire particle beam therapy system.
  • the particle beam therapy apparatus 100 includes a particle beam generator 52, a particle beam irradiation apparatus 41, and a plurality of deflecting electromagnets 55, which are connected via a beam transport system 59.
  • the particle beam generator 52 includes a pre-stage accelerator 53 including an ion source and a synchrotron 54, and charged particles (for example, proton ions or carbon ions) generated in the ion source are accelerated by the pre-stage accelerator 53.
  • the emitted particle beam is incident on the synchrotron 54.
  • the particle beam is accelerated by the synchrotron 54, is increased to a set energy, and is then emitted from the emission device.
  • the particle beam emitted from the synchrotron 54 reaches the particle beam irradiation device 41 through a beam transport system 59 including a plurality of deflection electromagnets 55 and a vacuum duct, and is placed on a treatment table from a particle beam irradiation nozzle (not shown).
  • the affected area of the patient is irradiated.
  • the deflection electromagnet 55 deflects the ion beam.
  • the magnetic field strength required for deflection varies depending on the beam energy.
  • the deflection electromagnet 55 includes a pair of main coils 2a and 2b having an annular shape, a pair of correction coils 3a and 3b having an annular shape disposed on the outer peripheral side of the main coils 2a and 2b, and a main coil.
  • the deflection electromagnet 55 is provided between the pair of magnetic pole cores 1a and 1b, the pair of magnetic pole cores 1a and 1b, and the pair of magnetic pole cores 1a and 1b, which are disposed on the inner peripheral side of 2a and 2b.
  • the deflection electromagnet 55 is provided.
  • the pair of magnetic cores 1a and 1b are made of a ferromagnetic material and are formed integrally with a yoke 1 formed so as to surround the main coils 2a and 2b and the correction coils 3a and
  • the distance s from the patient to the deflection electromagnet 55 closest to the patient is generally about 1 to 5 m from the irradiation site.
  • the accuracy required for the beam position at the irradiation site is about ⁇ 0.5 mm.
  • the deflection angle error of the deflection electromagnet 55 needs to be within ⁇ 0.5 mmrad.
  • the deflection electromagnet 55 is generally provided with correction coils 3a and 3b that share the main coils 2a and 2b and the magnetic cores 1a and 1b, respectively, because it is difficult to ensure accuracy only with the main coils 2a and 2b.
  • the deflection electromagnet 55 adjusts the excitation current of the correction coils 3a and 3b using the beam trajectory measurement result when only the main coils 2a and 2b are used, thereby reducing the trajectory error and ensuring accuracy. Adjustment is performed for each energy while the same energy is repeatedly transported.
  • FIG. 3 is a diagram showing an example of a beam monitor before and after correction using the correction coils 3a and 3b for the main coils 2a and 2b in the deflection electromagnet 55.
  • the cross lines 10x and 10y in FIG. 3 are vertical and horizontal center lines centered on the designed beam position.
  • the deflecting electromagnet 55 generally has a design error in the beam trajectory due to equipment installation error, manufacturing error, magnetic field setting error, etc., and deviated from the designed beam position. Beam position 11 is obtained.
  • the deflecting electromagnet 55 can adjust the beam passing position on the monitor according to the design from the measurement result of the beam monitor arranged in the transport system and the irradiation system.
  • the beam trajectory error of the entire irradiation system can be reduced, and the beam position can be set to the designed beam position 12.
  • FIG. 4 is a diagram for explaining an adjustment method when the magnetic field intensity in the deflection electromagnet 55 is changed in the particle beam therapy system 100 according to Embodiment 1 of the present invention.
  • FIG. 4A shows the change in the excitation current
  • FIG. 4B shows the relationship between the hysteresis loop and the excitation current.
  • FIG. 5 is a diagram showing an adjustment method in the case of the conventional bending electromagnet corresponding to FIG. 4B and 5B show the case where the iron core is excited from the demagnetized state, and the broken line shows a general hysteresis curve.
  • a deflection electromagnet generally behaves like a solid line because of a monopolar power supply.
  • the deflecting electromagnet 55 deflects the ion beam
  • the main coils 2a and 2b cause the first magnetic field strength higher than the target magnetic field strength to After the adjustment to the second magnetic field strength that is lower than the first magnetic field strength and higher than the target magnetic field strength by a predetermined amount, the correction coils 3a and 3b that share the main coils 2a and 2b and the magnetic pole cores 1a and 1b, respectively, An ion beam corrected to a target magnetic field strength is supplied to the irradiation system.
  • the deflection electromagnet 55 When the magnetic field strength is changed, the deflection electromagnet 55, as shown in FIG. 4A, after exciting to the maximum magnetic field strength to be saturated (I 1 ), the excitation current of the main coils 2a and 2b is changed to the target value of the magnetic field strength.
  • the target value B ob of the magnetic field strength is set on the hysteresis curve between I 1 and I 0 .
  • the predetermined amount is a value corresponding to a range within 1% of the maximum output of the deflection electromagnet 55.
  • the excitation of the correction coils 3a and 3b sharing the main coils 2a and 2b and the magnetic cores 1a and 1b is limited to the direction in which the excitation of the main coils 2a and 2b is canceled, so that the energy is switched during irradiation.
  • the magnetic field can be changed on the same hysteresis curve, so the difference between the energy change and the adjustment can be reduced, and the same beam state is maintained even after the energy change. be able to.
  • FIG. 6 is a diagram for explaining an adjustment method when the magnetic field strength in the deflecting electromagnet 55 is continuously changed a plurality of times in the particle beam therapy system 100 according to Embodiment 1 of the present invention.
  • FIG. 6A shows the change in the excitation current
  • FIG. 6B shows the relationship between the hysteresis loop and the excitation current.
  • FIG. 7 is a diagram showing an adjustment method in the case of the conventional bending electromagnet corresponding to FIG.
  • FIG. 8 is a diagram showing an example of an irradiation field irradiated with energy adjusted by the deflection electromagnet 55 in the particle beam therapy system 100 according to Embodiment 1 of the present invention.
  • the irradiation field is sliced in the depth direction D by slices S1, S2,.
  • slices S1, S2 In the case of irradiation by dividing as in (), it is necessary to change the energy of the beam irradiated to the patient.
  • the beam energy is changed by the particle beam generator 52 or the beam transport system 59, it is necessary to change the magnetic field intensity of the deflection electromagnet 55 in accordance with the beam energy.
  • the magnetic field strength changes a plurality of times, for each irradiation in each slice, after excitation up to the maximum magnetic field strength, the minimum magnetic field strength is set, and the operation of excitation up to the maximum magnetic field strength is repeated again, so-called initial stage After the process called crystallization, a method is adopted in which the magnetic field is set to a predetermined magnetic field strength from the maximum magnetic field strength, and after irradiation, the operation of excitation is repeated up to the maximum magnetic field strength again.
  • the initialization time usually takes about 1 minute, and there is a problem in improving the efficiency of the set time.
  • excitation is performed once to the maximum magnetic field strength (I 1 ), lowered to a predetermined magnetic field strength (I 2 ), and corrected (I 2 ⁇ I 3 ) in a direction to increase the magnetic field strength.
  • the deflection electromagnet 55 is first excited to the maximum magnetic field strength that is saturated (I 1 ), and then the main coil 2a.
  • the excitation current of 2b is set to be a predetermined amount higher than the target value B ob1 of the magnetic field intensity (I 2 ), and the excitation current of the correction coils 3a and 3b is corrected so that the magnetic field intensity by the main coils 2a and 2b becomes low. (I 2 ⁇ I 3 ).
  • the target value B ob1 of the magnetic field intensity is set on the hysteresis curve between I 1 and I 0 .
  • the beam supplied to the particle beam irradiation apparatus 41 by the beam irradiation system 59 including the deflection electromagnet 55 is irradiated to the slice S1 shown in FIG.
  • the deflection electromagnet 55 increases the excitation current of the main coils 2a and 2b by a predetermined amount from the target value Bob2 of the magnetic field intensity from the state of irradiating the slice S1 (I 3 ). (I 4 ), and the excitation currents of the correction coils 3a and 3b are corrected so that the magnetic field strength by the main coils 2a and 2b is reduced (I 4 ⁇ I 5 ).
  • the target value B ob2 of the magnetic field strength is set on the hysteresis curve between I 1 and I 0 . In this state, the beam supplied to the particle beam irradiation apparatus 41 by the beam irradiation system 59 including the deflection electromagnet 55 is irradiated to the slice S2 shown in FIG.
  • the deflection electromagnet 55 changes the excitation current of the main coils 2a and 2b from the target value B ob3 of the magnetic field intensity from the state where the slice S2 is irradiated (I 5 ).
  • the fixed amount is set to be high (I 6 ), and the excitation currents of the correction coils 3a and 3b are corrected so that the magnetic field strength by the main coils 2a and 2b is low (I 6 ⁇ I 7 ).
  • the target value B ob3 of the magnetic field strength is set on the hysteresis curve between I 1 and I 0 .
  • the beam supplied to the particle beam irradiation apparatus 41 by the beam irradiation system 59 including the deflection electromagnet 55 is irradiated to the slice S3 shown in FIG.
  • the predetermined amount is a value corresponding to a range within 1% of the maximum output of the deflection electromagnet 55.
  • the excitation of the correction coils 3a and 3b sharing the main coils 2a and 2b and the magnetic pole cores 1a and 1b is limited to the direction in which the excitation of the main coils 2a and 2b is canceled, so that the energy is continuously emitted.
  • the magnetic field can be changed on the same hysteresis curve as when repeatedly transporting the same energy, reducing the difference between energy change and adjustment without initialization each time the energy changes It is possible to maintain the same beam state as at the time of adjustment even after energy change.
  • the deflecting electromagnet 55 deflects the ion beam, and the main coils 2a and 2b allow the first higher magnetic field strength than the target.
  • the correction coils that share the main coils 2a and 2b and the magnetic pole cores 1a and 1b, respectively.
  • the energy is irradiated by limiting the excitation of the correction coil sharing the iron core to the direction to cancel the excitation of the main coil. Even when switching in, the magnetic field can be changed on the same hysteresis curve as when repeatedly transporting the same energy, so the energy It is possible to reduce the difference during adjustment and Saraji, after energy changes also can maintain the same beam conditions.
  • the magnetic field can be changed on the same hysteresis curve as when repeatedly transporting the same energy, so the energy can be changed without initialization each time the energy is changed.
  • the difference between time and adjustment can be reduced, and the same beam state can be maintained even after energy change.
  • setting data for each energy combination starting point, amount of change, and energy to be changed is not necessary, and setting data adjusted without changing beam energy can be applied. This shortens the setting time and minimizes the setting data of the deflection electromagnet by setting the deflection electromagnet with an arbitrary combination of excitation currents adjusted for each energy, and makes the deflection electromagnet the same state as at the time of adjustment. Therefore, the beam state can be made the same as that at the time of adjustment, and high-precision beam irradiation can be realized.
  • the present invention can be applied to at least one deflection electromagnet in a particle beam therapy system.
  • the embodiments can be appropriately modified and omitted within the scope of the invention.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un dispositif de thérapie par particules (100), des électro-aimants de déviation (55) qui dévient un faisceau d'ions tandis que l'intensité du champ magnétique est ajustée par des bobines principales (2a, 2b) depuis une première intensité de champ magnétique qui est supérieure à une intensité de champ magnétique cible vers une seconde intensité de champ magnétique qui est inférieure à la première intensité de champ magnétique mais supérieure à l'intensité de champ magnétique cible d'une quantité prédéterminée. L'intensité de champ magnétique est ensuite corrigée pour atteindre l'intensité de champ magnétique cible par des bobines de correction (3a, 3b) qui partagent des noyaux de fer polaire (1a, 1b) avec les bobines principales (2a, 2b). Par conséquent, même lorsque l'énergie du faisceau est commutée pendant l'irradiation, le champ magnétique des électro-aimants de déviation (55) peut être modifié sur la même courbe d'hystérésis dans le cas où la même énergie est délivrée de manière répétée, et le même état de faisceau que celui obtenu pendant l'ajustement peut être obtenu même après que l'énergie du faisceau a été modifiée.
PCT/JP2016/089207 2016-12-29 2016-12-29 Dispositif de thérapie par particules WO2018123063A1 (fr)

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Application Number Priority Date Filing Date Title
PCT/JP2016/089207 WO2018123063A1 (fr) 2016-12-29 2016-12-29 Dispositif de thérapie par particules
TW106121794A TW201822836A (zh) 2016-12-29 2017-06-29 粒子線治療裝置

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021229732A1 (fr) * 2020-05-13 2021-11-18
CN115148446A (zh) * 2021-03-30 2022-10-04 住友重机械工业株式会社 超导磁铁、粒子加速器及粒子束治疗装置

Citations (6)

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Publication number Priority date Publication date Assignee Title
JP2001137214A (ja) * 1999-11-12 2001-05-22 Hitachi Medical Corp 電源装置及びこれを用いた磁気共鳴イメージング装置
JP2002246200A (ja) * 2001-02-21 2002-08-30 Mitsubishi Electric Corp 粒子加速器の運転方法
JP2013165055A (ja) * 2012-10-10 2013-08-22 Mitsubishi Electric Corp セプタム電磁石の制御方法
JP2013215442A (ja) * 2012-04-10 2013-10-24 Hitachi Ltd 粒子線治療システム
JP2015220403A (ja) * 2014-05-20 2015-12-07 住友重機械工業株式会社 超伝導電磁石及び荷電粒子線治療装置
JP2016103357A (ja) * 2014-11-27 2016-06-02 株式会社東芝 加速器制御システム、加速器システムおよび加速器制御方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001137214A (ja) * 1999-11-12 2001-05-22 Hitachi Medical Corp 電源装置及びこれを用いた磁気共鳴イメージング装置
JP2002246200A (ja) * 2001-02-21 2002-08-30 Mitsubishi Electric Corp 粒子加速器の運転方法
JP2013215442A (ja) * 2012-04-10 2013-10-24 Hitachi Ltd 粒子線治療システム
JP2013165055A (ja) * 2012-10-10 2013-08-22 Mitsubishi Electric Corp セプタム電磁石の制御方法
JP2015220403A (ja) * 2014-05-20 2015-12-07 住友重機械工業株式会社 超伝導電磁石及び荷電粒子線治療装置
JP2016103357A (ja) * 2014-11-27 2016-06-02 株式会社東芝 加速器制御システム、加速器システムおよび加速器制御方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021229732A1 (fr) * 2020-05-13 2021-11-18
WO2021229732A1 (fr) * 2020-05-13 2021-11-18 株式会社日立ハイテク Dispositif à faisceau de particules chargées et procédé de commande de dispositif à faisceau de particules chargées
JP7361213B2 (ja) 2020-05-13 2023-10-13 株式会社日立ハイテク 荷電粒子線装置、荷電粒子線装置の制御方法
US12340970B2 (en) 2020-05-13 2025-06-24 Hitachi High-Tech Corporation Charged particle beam device, and method for controlling charged particle beam device
CN115148446A (zh) * 2021-03-30 2022-10-04 住友重机械工业株式会社 超导磁铁、粒子加速器及粒子束治疗装置

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