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WO2018134165A1 - Sonde médicale multifonctionnelle - Google Patents

Sonde médicale multifonctionnelle Download PDF

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Publication number
WO2018134165A1
WO2018134165A1 PCT/EP2018/050921 EP2018050921W WO2018134165A1 WO 2018134165 A1 WO2018134165 A1 WO 2018134165A1 EP 2018050921 W EP2018050921 W EP 2018050921W WO 2018134165 A1 WO2018134165 A1 WO 2018134165A1
Authority
WO
WIPO (PCT)
Prior art keywords
probe
sheath
longitudinal axis
proximal end
containers
Prior art date
Application number
PCT/EP2018/050921
Other languages
German (de)
English (en)
Inventor
Helmut Schmid
Wilhelm Eckl
Peter Scholz
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. filed Critical Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
Publication of WO2018134165A1 publication Critical patent/WO2018134165A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09083—Basic structures of guide wires having a coil around a core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069—Tip not integral with tube

Definitions

  • the present invention relates to a multifunctional medical probe and its use.
  • Probes or catheters are tubes or tubes of various diameters made of plastic, rubber, silicone, metal or glass, with which hollow organs such as bladder, stomach, intestine, vessels, but also ear and heart can be probed, emptied, filled or rinsed. This happens for diagnostic (research-related) or therapeutic (treatment-related) reasons.
  • probes have inadequate antimicrobial finish, so that, especially in postoperative periods, it becomes a bacterial inflammation in the treated Tissue or the treated hollow organs, such as urinary bladder, stomach, intestine, vessels, but also ear and heart can come.
  • a major disadvantage of the previously known medical probes is that they have insufficient controllability.
  • Controllable catheters are used, for example, in interventional cardiology, where they are navigated within the vascular system to stenoses or occlusions. In the electrotherapy of the heart, they are used to place stimulation or measuring electrodes on the heart. Special problems are the navigation of a catheter to the left side of the heart.
  • Further known disadvantages of medical probes are the lack of efficient possibility for the application of active substances and a lack of multifunctionality of the medical probes. There is therefore a particular need for medical probes with which a targeted delivery of active ingredients into desired regions (targeted drug deliverables or with which the kinetics of the application of active substances (controlled drug release) is possible. that the medical probe in the application in the human or animal body is well controlled.
  • the medical probe should have good sliding properties as well as improved microbial equipment. Furthermore, the medical probe should preferably have a pronounced multifunctionality, so that the medical probe can be used for different fields of application.
  • the present invention has the object to provide a medical probe, which allows an effective and simple, but preferably precisely controllable application of active substances.
  • a medical probe having a distal end and a proximal end, comprising
  • the probe according to the invention is formed, in particular, in that the pointed probe head has an asymmetrical shape with respect to the longitudinal axis of the probe and can be tilted by rotating the common arrangement of polycarbonate strand, first sheath and second sheath relative to the longitudinal axis of the polycarbonate strand.
  • the twisting of the common arrangement of polycarbonate strand, first sheath and second sheath takes place, as described below, against the probe sheath. This simplifies the navigation with the medical probe according to the invention.
  • Figure 1 represents the inventive medical medical probe in cross section
  • Figure 2 the profile of the medical probe according to the invention in the direction of the longitudinal axis of the medical probe.
  • the Schmuno 1 shows a medical probe 1 according to the invention in cross section.
  • the medical probe 1 has a distal end 1a and a proximal end 1b.
  • the manipulation of the medical probe 1 by the user takes place.
  • an optical light source can be connected to the proximal end 1b of the medical probe or a supply of a gas (gas inlet) can be provided.
  • gas inlet gas inlet
  • the exact configuration of the connection of a light source and a gas inlet at the proximal end of the medical probe 1 are well known to those skilled in the art.
  • the medical probe 1 is inserted into the human or animal body via the distal end 1a.
  • the medical probe 1 comprises a pofycarbonate strand 2 in the inner core.
  • This polycarbonate strand 2 extends over the substantially entire length of the medical probe 1, which is defined in greater detail below. Accordingly, the polycarbonate strand 2 analogously has a distal end 2a and a proximal end 2b. In addition, the polycarbonate strand 2 defines the longitudinal axis of the medical probe 1 according to the invention.
  • Polycarbonate is used for the inner core because the material is a good light guide, becomes only slightly brittle and therefore rarely breaks.
  • a lens head 11 is preferably provided at the distal end of the polycarbonate strand.
  • the lens head 11 allows the user to view the application at the digital end of the medical probe.
  • the diameter of the polycarbonate strand 2 is generally 0.2 to 1.0 mm, preferably 0.3 to 0.8 mm, more preferably 0.4 to 0.6 mm.
  • a first sheath 3 is provided in the medical probe 1. This cladding is made opaque to light rays, so that the inner polycarbonate strand 2 is substantially shielded from the light supplied by the third cladding.
  • the first sheath 3 is formed, for example, from a thermoplastic elastomer (TPE).
  • TPE thermoplastic elastomer
  • the radial layer thickness of the sheath 3 is generally 0.6 to 2.4 mm, preferably 0.8 to 2.2 mm, more preferably 1 to 2 mm. If the medical probe is used as a catheter, the radial layer thickness of the sheath 3 is generally 2 to 4 mm.
  • the first sheath 3 can be used with the radial profile provided in FIG.
  • at least one channel 9, which can serve to introduce gases is formed.
  • the introduction of a gas into the channel 9 can be used to widen the examination volume, for example the abdomen.
  • gaseous carbon dioxide (C0 2 ) and subsequent expansion on the probe head 5 the gas in the channel 9 can be used to freeze tissue and ablate by the resulting scalpel action of the probe head 5.
  • Another function of the channel 9 in the first sheath 3 is the discharge of body fluids via the probe head 5. This may be, for example, lymph, urine or pus.
  • the exact configuration of the outlet of the channel 9 on the probe head 5 is well known to those skilled in the art.
  • the sheath 3 is surrounded by a further radially arranged sheath 4, which can act as a light guide.
  • This sheath 4 is preferably by formed a Poiycarbonatschlauch.
  • the sheath 4, if the sheath is used as a source of illumination, may be connected to a radiation source on the proximal side of the medical probe 1.
  • the radial layer thickness of the sheath 4 is generally 0.2 to 1.0 mm, preferably 0.3 to 0.8 mm, more preferably 0.4 to 0.6 mm.
  • a probe head 5 is provided at the distal end 1a of the probe 1.
  • This probe head 5 is preferably also formed from a polycarbonate. The reason for the use of polycarbonate as a material has already been explained above.
  • the probe head 5 is preferably positively and non-positively connected to the polycarbonate strand 2, the first sheath 3, the second sheath 4 and the front container 8a, whose operation will be described below.
  • the probe head 5 of the medical probe 1 is designed to be movable.
  • the mobility of the probe head 5 is ensured by the fact that the unit of polycarbonate strand 2, first sheath 3 and second sheath 4 is rotated about the longitudinal axis of the medical probe 1. More specific embodiments for the rotatability of the probe head 5 will be discussed below.
  • the second sheath 4 is provided in the probe 1 according to the invention with a further third sheath 6, which extends radially along the longitudinal axis of the medical probe 1.
  • the third sheath 6 may be, for example, a guidewire 7.
  • the guide wire 7 may preferably be formed spirally.
  • the guidewire which is preferably formed of a stainless steel material, generally has a diameter of 1.00 to 3.00 mm, preferably 1.25 to 2.75 mm, more preferably 1.50 to 2.50 mm.
  • containers 8 are also provided in a preferred embodiment, which are positively and non-rotatably connected to the guide wire 7 or are threaded on the sheathing.
  • These individual containers are preferably formed from a polymer material that has different hardness and porosity depending on the container. It is further preferred that the hardness of the container 8 increases from the probe head 5 in the direction of the proximal end 1b of the medical probe 1 and that the porosity of the container 8 decreases from the probe head 5 in the direction of the proximal end 1b of the medical probe 1. It follows that, in a preferred embodiment, the hardness of the containers increases in the direction 8a - »8b -> 8c -> 8d -» 8e (as shown in Figure 1).
  • the porosity of the containers decreases in the direction 8a -> 8b -> 8c -> 8d -> 8e (as shown in Figure 1)
  • the hardness and porosity of the container 8 can be controlled by the pore number, the pore size and / or the material selection of the individual containers 8.
  • the individual containers 8a to 8e are preferably designed as hollow bodies, so that a filling material can be introduced into the containers 8a to 8e.
  • the individual containers 8a to 8e are made of polyurethane foams having a pore size of generally 0.01 to 2.50 mm, preferably 0.05 to 2.00 mm, more preferably 0.10 to 1.00 mm, wherein the pore size may vary from container to container to adjust the hardness and porosity of the individual containers.
  • Hydrogelmateriallen can be introduced, in which, for example, drugs are embedded.
  • Suitable drugs for this purpose include anticoagulants, such as heparins and / or coumarins, blood coagulants, such as tranexamic acid; Cardiac glycosides, such as digitoxin; Anticancer agents, such as anthracyclines (e.g., optionally encapsulated doxorubicin); Local anesthetic, such as lidocaine, procaine the derivatives thereof; or analgesics, such as acetylsalicylic acid, diclofenac and ibuprofen.
  • anticoagulants such as heparins and / or coumarins
  • blood coagulants such as tranexamic acid
  • Cardiac glycosides such as digitoxin
  • Anticancer agents such as anthracyclines (e.g., optionally encapsulated doxorubicin); Local anesthetic, such as lidocaine, procaine the derivatives thereof; or analgesics, such as
  • the drugs are preferably present in biocompatible fluids.
  • a suitable biocompatible liquid is, for example, a polyethylene glycol whose viscosity can be varied (for example, by varying the number of carbon atoms of the polyethylene glycol). By varying the viscosity of the biocompatible fluids, the hardness of the individual containers can be further adjusted.
  • controllable release of the active substances from the containers is understood to mean that the active substances of a defined and predefined container can be released by using specific measures.
  • the containers 8 are initially connected with the guidewire 7 in a positive and non-positive manner and together with the guidewire form the outer probe sheath.
  • the release of the drugs from the container is then preferably such that the polycarbonate strand 2 is retracted together with the first sheath 3 and the second sheath 4 in the proximal direction relative to the guide wire and the containers 8 parallel to the longitudinal axis of the medical probe 1.
  • the remaining containers preferably containers 8b to 8e in the embodiment according to FIG. 1 are then successively under such great tension. implies that they, too, released the corresponding active ingredients.
  • This squeezing of the container 8a to 8e allows a targeted application of the active ingredients in the desired region (target drug delivery).
  • the kinetics of drug release can be influenced by the pulling speeds in the direction of the proximal end of the medical probe 1 (controlled drug release).
  • the containers 8a to 8e have a porosity of 0.1 to 1.0, preferably 0.2 to 0.8, more preferably 0.3 to 0.6.
  • the medical probe 1 generally has 1 to 10 containers, preferably 1 to 5 containers 8.
  • the successive release of the container contents, starting from the distal end 1a, takes place in the direction of the proximal end 1b of the medical probe 1.
  • the probe head 5 is preferably mounted free of the containers 8 (in particular container 8a).
  • the probe head 5 of the medical probe 1 with respect to the longitudinal axis of the probe 1, is formed asymmetrically, i. the beveled side (11a, 11b) of the probe head (5), relative to the longitudinal axis of the probe (1), are asymmetrical to one another.
  • a coating may be provided on the outer probe shell, which is formed by the guide wire 7 and the container 8.
  • the coating of the probe cover can reduce as possible the resistance during insertion of the medical probe 1 into the human or animal body.
  • coatings selected from the group consisting of a Hydrogeibe Anlagenung, a polyolefin coating, a fluorocarbon coating, a Poiysiloxanbe harshung and mixtures of the aforementioned coatings.
  • the fluorocarbon coating is preferably selected from the group consisting of polyvinyl tetrafluoride, polyvinylidene fluoride and polyvinyl fluoride.
  • Copolymers of fluorocarbons are preferably perfluoroalkoxy polymers (PFA), for example copolymers of tetrafluoroethylene and perfluoro-vinyl-methyl-ether.
  • PFA perfluoroalkoxy polymers
  • the fluorinated hydrocarbons are not perfluorinated hydrocarbons. Due to a reduced proportion of fluorine atoms per repeat unit, in this embodiment the adhesion of the polymer layer can be optimized on the fabric. More preferably, in this embodiment, the repeat units of the fluorinated hydrocarbons have a ratio of hydrogen to fluorine of 1: 1.
  • Polysiloxanes are inventively preferred polymers for the polymer layer. By means of these, in particular, a surface can be obtained which meets the hydrophobicity criteria of the present invention.
  • the polysiloxanes are preferably polysiloxane resins, i. polysiloxanes with a correspondingly high degree of branching or linear polysiloxanes, such as, for example, hydrosilyl polydimethylsiloxane, which are subsequently crosslinked.
  • Copolymers of polysiloxanes preferably comprise polyether-polysiloxanes, polymethylsiloxane-polyalkylsiloxane or polymethylsiloxane-polyalkylsiloxane polyethers.
  • the coating of the medical probe 1 may additionally contain chitosan or at least one chitosan derivative.
  • the coating provided according to the invention may additionally contain silver in nanoparticulate form.
  • the particles of the elemental silver generally have an average particle size (diameter) of less than 500.00 nm, more preferably less than 100.00 nm, more preferably less than 50.00 nm. Particularly effective is an average particle size of 5.00 to 50.00 nm.
  • the nanoparticulate silver even more preferably has an average particle size of 2.50 to 25.00 nm, preferably 3.75 to 20.00 nm, more preferably 5.00 to 15.00 mm, on.
  • the particle size is determined by photon correlation spectroscopy.
  • the medical probe coating 1 may contain chitosan and / or a chitosan derivative.
  • Chitosan which can be used according to the invention has, for example, a molecular weight of 3,000 to 700,000 and is commercially available (see, for example, EP-A-0 377091).
  • the nanoparticulate silver and the chitosan can act synergistically to a certain extent, whereby the mode of action of the chitosan in conjunction with the used nanoparticulate silver is based on the fact that a possibly occurring bacterial growth takes place according to different mechanisms, whereby also biochemical processes with the building up of the cell wall of the bacteria meaningful.
  • Chitosan interferes with the metabolism to form the chitin cell walls and thus prevents cell growth. It is surprising that the chitosan unfolds this effect even under the special chemical conditions of a coating of medical probes 1.
  • the medical probe 1 according to the invention has an overall diameter of generally 4.00 to 8.00 mm, preferably 4.50 to 7.50 mm, more preferably 5.00 to 7.00 mm.
  • the total length of the medical probe 1 is generally from 1.00 to 3.00 m, preferably from 1.25 to 2.75 m, more preferably from 1.50 to 2.50 m.
  • the medical probe 1 according to the invention can be equipped with a sensor.
  • the sensor may be an ultrasonic sensor.
  • the medical probe 1 may be a balloon probe.
  • the above-described medical probe 1 may be for use in endoscopy, diagnostics, supply and discharge of media, and a surgical tool.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une sonde médicale multifonctionnelle permettant une bonne navigation dans le corps humain et animal, ainsi qu'une libération ciblée d'agents.
PCT/EP2018/050921 2017-01-23 2018-01-16 Sonde médicale multifonctionnelle WO2018134165A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017101190.0A DE102017101190A1 (de) 2017-01-23 2017-01-23 Multifunktionelle medizinische Sonde
DE102017101190.0 2017-01-23

Publications (1)

Publication Number Publication Date
WO2018134165A1 true WO2018134165A1 (fr) 2018-07-26

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ID=61003015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/050921 WO2018134165A1 (fr) 2017-01-23 2018-01-16 Sonde médicale multifonctionnelle

Country Status (2)

Country Link
DE (1) DE102017101190A1 (fr)
WO (1) WO2018134165A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377091A1 (fr) 1988-11-28 1990-07-11 Societe Des Produits Nestle S.A. Préparation cosmétique contenant du chitosane
WO1991014395A1 (fr) * 1990-03-19 1991-10-03 Target Therapeutics Fil de guidage a bout distal flexible
DE69029382T2 (de) * 1989-09-08 1997-06-12 Slt Japan Kk Vorrichtung zur bestrahlung mit einem laserstrahl
DE102004028367A1 (de) * 2004-06-11 2005-12-29 Biotronik Vi Patent Ag Katheter-Führungsdraht insbesondere für kardio-vaskuläre Eingriffe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11225951A (ja) 1998-02-17 1999-08-24 Olympus Optical Co Ltd 内視鏡用処置具

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377091A1 (fr) 1988-11-28 1990-07-11 Societe Des Produits Nestle S.A. Préparation cosmétique contenant du chitosane
DE69029382T2 (de) * 1989-09-08 1997-06-12 Slt Japan Kk Vorrichtung zur bestrahlung mit einem laserstrahl
WO1991014395A1 (fr) * 1990-03-19 1991-10-03 Target Therapeutics Fil de guidage a bout distal flexible
DE102004028367A1 (de) * 2004-06-11 2005-12-29 Biotronik Vi Patent Ag Katheter-Führungsdraht insbesondere für kardio-vaskuläre Eingriffe

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