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WO2018136163A3 - Tandem apoa-1 fusion polypeptides - Google Patents

Tandem apoa-1 fusion polypeptides Download PDF

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Publication number
WO2018136163A3
WO2018136163A3 PCT/US2017/065078 US2017065078W WO2018136163A3 WO 2018136163 A3 WO2018136163 A3 WO 2018136163A3 US 2017065078 W US2017065078 W US 2017065078W WO 2018136163 A3 WO2018136163 A3 WO 2018136163A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion polypeptides
apoa
polypeptide
disclosed
fusion
Prior art date
Application number
PCT/US2017/065078
Other languages
French (fr)
Other versions
WO2018136163A2 (en
Inventor
Martha S. Hayden-Ledbetter
Jeffrey A. Ledbetter
Vince Montes
Original Assignee
Theripion, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theripion, Inc. filed Critical Theripion, Inc.
Publication of WO2018136163A2 publication Critical patent/WO2018136163A2/en
Publication of WO2018136163A3 publication Critical patent/WO2018136163A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Compositions and methods relating to ApoA-1 fusion polypeptides are disclosed. In particular embodiments, the fusion polypeptides include first and second polypeptide segments joined in tandem via a linker, each segment corresponding to an ApoA-1 polypeptide or ApoA-1 mimetic. Fusion polypeptides may also include a dimerizing domain or domain that specifically binds the neonatal Fc receptor (e.g., an Fc region or albumin), which is typically linked carboxyl-terminal to the second polypeptide segment via a flexible linker. In some embodiments, the fusion polypeptide further includes an additional polypeptide segment conferring a second biological activity (e.g., an RNase, paraoxonase, platelet-activating factor acetylhydrolase, cholesterol ester transfer protein, lecithincholesterol acyltransferase, or polypeptide that specifically binds to amyloid beta). Also disclosed are dimeric proteins comprising first and second ApoA-1 fusion polypeptides comprising a dimerizing domain as disclosed herein. The fusion polypeptides and dimeric proteins are useful in methods for therapy.
PCT/US2017/065078 2016-12-09 2017-12-07 Tandem apoa-1 fusion polypeptides WO2018136163A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662432128P 2016-12-09 2016-12-09
US62/432,128 2016-12-09
US201762467288P 2017-03-06 2017-03-06
US62/467,288 2017-03-06

Publications (2)

Publication Number Publication Date
WO2018136163A2 WO2018136163A2 (en) 2018-07-26
WO2018136163A3 true WO2018136163A3 (en) 2018-09-27

Family

ID=62152610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/065078 WO2018136163A2 (en) 2016-12-09 2017-12-07 Tandem apoa-1 fusion polypeptides

Country Status (1)

Country Link
WO (1) WO2018136163A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114578046A (en) * 2020-11-30 2022-06-03 广东菲鹏生物有限公司 Novel coronavirus (SARS-CoV-2) antibody detection reagent
AU2022224584A1 (en) 2021-02-19 2023-09-21 Theripion, Inc. Paraoxonase fusion polypeptides and related compositions and methods

Citations (1)

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WO2002038609A2 (en) * 2000-11-10 2002-05-16 Proteopharma Aps Apolipoprotein conjugates

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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
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Also Published As

Publication number Publication date
WO2018136163A2 (en) 2018-07-26

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