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WO2018136163A3 - Polypeptides de fusion apoa-1 en tandem - Google Patents

Polypeptides de fusion apoa-1 en tandem Download PDF

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Publication number
WO2018136163A3
WO2018136163A3 PCT/US2017/065078 US2017065078W WO2018136163A3 WO 2018136163 A3 WO2018136163 A3 WO 2018136163A3 US 2017065078 W US2017065078 W US 2017065078W WO 2018136163 A3 WO2018136163 A3 WO 2018136163A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion polypeptides
apoa
polypeptide
disclosed
fusion
Prior art date
Application number
PCT/US2017/065078
Other languages
English (en)
Other versions
WO2018136163A2 (fr
Inventor
Martha S. Hayden-Ledbetter
Jeffrey A. Ledbetter
Vince Montes
Original Assignee
Theripion, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theripion, Inc. filed Critical Theripion, Inc.
Publication of WO2018136163A2 publication Critical patent/WO2018136163A2/fr
Publication of WO2018136163A3 publication Critical patent/WO2018136163A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des compositions et des procédés relatifs aux polypeptides de fusion ApoA-1. Dans des modes de réalisation particuliers, les polypeptides de fusion comprennent des premier et second segments polypeptidiques reliés en tandem par l'intermédiaire d'un lieur, chaque segment correspondant à un polypeptide ApoA-1 ou un mimétique d'ApoA-1. Les polypeptides de fusion peuvent également comprendre un domaine de dimérisation ou un domaine qui se lie spécifiquement au récepteur Fc néonatal (par exemple, une région Fc ou une albumine), qui est typiquement lié côté carboxyle-terminal au second segment polypeptidique par l'intermédiaire d'un lieur flexible. Dans certains modes de réalisation, le polypeptide de fusion comprend en outre un segment polypeptidique supplémentaire qui confère une seconde activité biologique (par exemple, RNase, paraoxonase, acétylhydrolase du facteur d'activation plaquettaire, protéine de transfert d'ester de cholestérol, lécithine-cholestérol acyltransférase ou polypeptide qui se lie de manière spécifique à l'amyloïde bêta). L'invention concerne également des protéines dimériques comprenant des premier et second polypeptides de fusion ApoA-1 comprenant un domaine de dimérisation tel que décrit dans la présente invention. Les polypeptides de fusion et les protéines dimériques sont utiles dans des méthodes thérapeutiques.
PCT/US2017/065078 2016-12-09 2017-12-07 Polypeptides de fusion apoa-1 en tandem WO2018136163A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662432128P 2016-12-09 2016-12-09
US62/432,128 2016-12-09
US201762467288P 2017-03-06 2017-03-06
US62/467,288 2017-03-06

Publications (2)

Publication Number Publication Date
WO2018136163A2 WO2018136163A2 (fr) 2018-07-26
WO2018136163A3 true WO2018136163A3 (fr) 2018-09-27

Family

ID=62152610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/065078 WO2018136163A2 (fr) 2016-12-09 2017-12-07 Polypeptides de fusion apoa-1 en tandem

Country Status (1)

Country Link
WO (1) WO2018136163A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114578046A (zh) * 2020-11-30 2022-06-03 广东菲鹏生物有限公司 新型冠状病毒(SARS-CoV-2)抗体检测试剂
AU2022224584A1 (en) 2021-02-19 2023-09-21 Theripion, Inc. Paraoxonase fusion polypeptides and related compositions and methods

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Publication number Priority date Publication date Assignee Title
WO2002038609A2 (fr) * 2000-11-10 2002-05-16 Proteopharma Aps Analogues d'apolipoproteine

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Also Published As

Publication number Publication date
WO2018136163A2 (fr) 2018-07-26

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