[go: up one dir, main page]

ZA976853B - Preparation of narcotic analgesics. - Google Patents

Preparation of narcotic analgesics.

Info

Publication number
ZA976853B
ZA976853B ZA9706853A ZA976853A ZA976853B ZA 976853 B ZA976853 B ZA 976853B ZA 9706853 A ZA9706853 A ZA 9706853A ZA 976853 A ZA976853 A ZA 976853A ZA 976853 B ZA976853 B ZA 976853B
Authority
ZA
South Africa
Prior art keywords
narcotic analgesics
preparation
hydromorphone
hydrocodone
disclosed
Prior art date
Application number
ZA9706853A
Other languages
English (en)
Inventor
Bogdan Mudryk
Joydeep Kant
Chester Sapino
Original Assignee
Johnson Matthey Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Plc filed Critical Johnson Matthey Plc
Publication of ZA976853B publication Critical patent/ZA976853B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Plant Substances (AREA)
ZA9706853A 1996-08-01 1997-07-31 Preparation of narcotic analgesics. ZA976853B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9616253.2A GB9616253D0 (en) 1996-08-01 1996-08-01 Preparation of narcotic analgesics

Publications (1)

Publication Number Publication Date
ZA976853B true ZA976853B (en) 1998-02-11

Family

ID=10797912

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9706853A ZA976853B (en) 1996-08-01 1997-07-31 Preparation of narcotic analgesics.

Country Status (15)

Country Link
US (1) US5847142A (fr)
EP (1) EP0915884B1 (fr)
JP (2) JP4316674B2 (fr)
CN (1) CN1105721C (fr)
AT (1) ATE215955T1 (fr)
AU (1) AU3629197A (fr)
DE (1) DE69711883T2 (fr)
DK (1) DK0915884T3 (fr)
ES (1) ES2175438T3 (fr)
GB (1) GB9616253D0 (fr)
MY (1) MY117858A (fr)
PL (1) PL186307B1 (fr)
TW (1) TW396157B (fr)
WO (1) WO1998005667A1 (fr)
ZA (1) ZA976853B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics
ATE500257T1 (de) * 1999-11-09 2011-03-15 Abbott Lab Hydromorphinonzusammensetzungen
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103405431B (zh) * 2002-05-17 2016-04-13 台湾J药品有限公司 阿片和阿片样化合物及其用途
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
AU2004319925B2 (en) * 2002-11-11 2010-12-09 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
WO2005047291A1 (fr) * 2002-11-11 2005-05-26 Mallinckrodt Inc. Procede de production catalytique d'hydrocodone et d'hydromorphone
US7323565B2 (en) * 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) * 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7321038B2 (en) * 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
US7348430B2 (en) * 2005-01-21 2008-03-25 Acura Pharmaceuticals, Inc. Production of opioid analgesics
AU2006229734A1 (en) 2005-03-28 2006-10-05 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
WO2006138020A2 (fr) * 2005-06-16 2006-12-28 Mallinckrodt Inc. Trajet synthetique vers 14-hydroxyl opiates via 1-halo-thebaine ou analogues
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
CA2637610A1 (fr) * 2007-05-04 2008-11-04 Mallinckrodt Inc. Procede ameliore de preparation de 6-alpha-hydroxyopiates n- alkyles
US7999104B2 (en) 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
JP2010533719A (ja) * 2007-07-17 2010-10-28 マリンクロッド・インコーポレイテッド 還元的アミノ化によるｎ−アルキル化オピエートの調製
NZ592005A (en) 2008-09-30 2013-03-28 Mallinckrodt Llc Process for the preparation of a N-alkylated ketomorphinan by selective catalytiC hydrogen transfer reduction
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010118275A1 (fr) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Préparation de composés cétone morphinanes saturées
WO2010118274A1 (fr) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Préparation de 6-céto, 3-alcoxy morphinanes
US8293907B2 (en) * 2009-04-09 2012-10-23 Mallinckrodt Inc. Preparation of saturated ketone morphinan compounds by catalytic isomerization
CN102803267A (zh) * 2009-06-11 2012-11-28 马林克罗特有限公司 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备
EP2440561B1 (fr) * 2009-06-11 2014-04-30 Mallinckrodt LLC Amination reductrice de 6-ceto normorphinanes par transfert catalytique d'hydrogene
SI2506712T1 (sl) 2009-12-04 2019-06-28 Alkermes Pharma Ireland Limited, Derivati morfinana za zdravljenje prevelikega odmerka mamil
CA2936749C (fr) 2010-06-11 2019-07-09 Joshua R. Giguere Procedes catalyses par metal de transition pour la preparation de composes de n-allyle et utilisation de ceux-ci
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
US8703950B2 (en) 2010-07-02 2014-04-22 Johnson Matthey Public Limited Co. Low ABUK oxycodone, its salts and methods of making same
ES2708726T3 (es) * 2010-07-08 2019-04-10 Alkermes Pharma Ireland Ltd Proceso para la síntesis de morfinanos sustituidos
DK2608670T3 (en) 2010-08-23 2019-02-11 Alkermes Pharma Ireland Ltd METHOD OF TREATING ANTI-SOCIETY-INDICATED WEIGHT RISE
CN103619847A (zh) 2011-05-06 2014-03-05 布鲁克大学 通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法
US9296699B2 (en) 2011-06-09 2016-03-29 Mallinckrodt Llc Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
CA2845187A1 (fr) 2011-09-08 2013-03-14 Peter X. Wang Production d'alcaloides sans l'isolement d'intermediaires
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
NZ631018A (en) 2013-05-24 2017-12-22 Alkermes Pharma Ireland Ltd Morphan and morphinan analogues, and methods of use
WO2014190271A2 (fr) 2013-05-24 2014-11-27 Alkermes Pharma Ireland Limted Méthodes de traitement de symptômes de la dépression
GB201313211D0 (en) 2013-07-24 2013-09-04 Cambrex Karlskoga Ab New process
EP3255051A1 (fr) 2016-06-09 2017-12-13 Siegfried AG Catalyseur métallique supporté pour la production d' hydrocodone et hydromorphon
US10081636B2 (en) 2016-07-08 2018-09-25 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
WO2022101444A1 (fr) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Comprimé multicouche à libération immédiate
EP4244226A1 (fr) 2020-11-13 2023-09-20 Ferrer Internacional, S.A. Synthèse d'une base d'hydromorphone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) * 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2715626A (en) * 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
FR1290174A (fr) * 1961-01-25 1962-04-13 S E M P A Chemie Préparation de la codéïnone à partir de la thébaïne
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics

Also Published As

Publication number Publication date
MY117858A (en) 2004-08-30
JP2009161557A (ja) 2009-07-23
EP0915884A1 (fr) 1999-05-19
ES2175438T3 (es) 2002-11-16
GB9616253D0 (en) 1996-09-11
CN1105721C (zh) 2003-04-16
PL331525A1 (en) 1999-07-19
WO1998005667A1 (fr) 1998-02-12
JP2001500846A (ja) 2001-01-23
JP4316674B2 (ja) 2009-08-19
DE69711883T2 (de) 2002-10-31
CN1231667A (zh) 1999-10-13
EP0915884B1 (fr) 2002-04-10
ATE215955T1 (de) 2002-04-15
PL186307B1 (pl) 2003-12-31
AU3629197A (en) 1998-02-25
DK0915884T3 (da) 2002-07-01
US5847142A (en) 1998-12-08
TW396157B (en) 2000-07-01
DE69711883D1 (de) 2002-05-16

Similar Documents

Publication Publication Date Title
ZA976853B (en) Preparation of narcotic analgesics.
EG21200A (en) Process for preparing organometallic addition to ketones
DE69726714D1 (en) 9-oximsilyl erythromycin a derivate
IL127348A0 (en) Process for preparing imidazoquinolinamines
HUT63416A (en) New process for producing imidazo/4,5-c/quinoline-4-amine derivatives
AU5148093A (en) Process for combining transmitter-receiver pairs of a cordless communications system to form a communicationg unit
EP0636117A4 (fr) Procede d'administration de pyruvate et procedes de synthese de precurseurs de pyruvate.
GB2185754B (en) Process for producing gasoline
ZA899208B (en) Process for intermediate compounds for preparing penems and carbapenems
CA2241014A1 (fr) Derives de morphine a activite analgesique
GB2201151B (en) Process for producing statin and related compounds
AU6791390A (en) Method for treatment of cocaine and heroin addiction comprising transdermal delivery of buprenorphine
IL122004A0 (en) Producing process of (fluoroaryl) borane compound and producing process of tetrakis (fluoroaryl) borate derivative
AU8229887A (en) Process for producing pig iron
EP0471790A4 (en) Method for localization and treatment of tumors and complexes therefor
GB8624077D0 (en) Organometallic complexes of magnesium
GB2272702B (en) A process for the preparation of aluminium-heavy metal mixed complexes
ZA878381B (en) Improved process for preparing organometallic compounds
ZA894989B (en) Process for decomposition of metal-cyano complexes using microbial enzymes
EP0742221A3 (fr) Procédé de préparation de treméthylaluminium
AU617577B2 (en) Method for preparing catalyst precursor for methanol synthesis
AU7421487A (en) Ligands and methods for augmenting b-cell proliferation
AU3064895A (en) Process for preparing transition metal complexes containing disubstituted cyclopentadienyl ligands
CA2261675A1 (fr) Preparation d'analgesiques narcotiques
MX9700523A (es) Procedimiento para la preparacion de enantiomeros de o-demetiltramadol.