ATE212342T1 - Zwischerprodukte für die hemisynthese von taxanen und deren verfahren zu herstellung - Google Patents

Zwischerprodukte für die hemisynthese von taxanen und deren verfahren zu herstellung

Info

Publication number: ATE212342T1
Authority: AT; Austria
Prior art keywords: hemisynthesis; taxans; production; intermediate products; taxane
Prior art date: 1995-10-27

Application number

AT96934977T

Other languages

English (en)

Inventor

Luc Chanteloup

Bruno Chauveau

Christine Corbin

Robert Dhal

Guen Sonia Le

Arnaud Lamy

Antoine Leze

Jean-Pierre Robin

Original Assignee

Seripharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-27

Filing date

1996-10-25

Publication date

2002-02-15

1996-10-25 Application filed by Seripharm filed Critical Seripharm

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212342T1 publication Critical patent/ATE212342T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0838—Compounds with one or more Si-O-Si sequences
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Plant Substances (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96934977T 1995-10-27 1996-10-25 Zwischerprodukte für die hemisynthese von taxanen und deren verfahren zu herstellung ATE212342T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9512739A FR2740451B1 (fr)	1995-10-27	1995-10-27	Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
PCT/FR1996/001676 WO1997015562A1 (fr)	1995-10-27	1996-10-25	Intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation

Publications (1)

Publication Number	Publication Date
ATE212342T1 true ATE212342T1 (de)	2002-02-15

Family

ID=9484016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96934977T ATE212342T1 (de)	1995-10-27	1996-10-25	Zwischerprodukte für die hemisynthese von taxanen und deren verfahren zu herstellung

Country Status (25)

Country	Link
US (5)	US6265587B1 (de)
EP (1)	EP0863887B1 (de)
JP (1)	JP2000500437A (de)
KR (1)	KR100489865B1 (de)
CN (1)	CN100374428C (de)
AT (1)	ATE212342T1 (de)
AU (1)	AU710314B2 (de)
BR (1)	BR9610908A (de)
CZ (1)	CZ125598A3 (de)
DE (1)	DE69618812T2 (de)
DK (1)	DK0863887T3 (de)
EE (1)	EE03610B1 (de)
ES (1)	ES2170876T3 (de)
FR (1)	FR2740451B1 (de)
GE (1)	GEP20001938B (de)
HU (1)	HU225507B1 (de)
IL (1)	IL155876A (de)
NO (1)	NO981823L (de)
NZ (1)	NZ320356A (de)
PL (1)	PL327458A1 (de)
PT (1)	PT863887E (de)
RU (1)	RU2159237C2 (de)
SK (1)	SK52398A3 (de)
TR (1)	TR199800713T2 (de)
WO (1)	WO1997015562A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2740451B1 (fr) *	1995-10-27	1998-01-16	Seripharm	Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
KR100225535B1 (ko) *	1996-08-27	1999-10-15	정지석	파클리탁셀의 제조방법
US6150537A (en) *	1997-12-12	2000-11-21	Emory University	Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
KR100267596B1 (ko) *	1998-04-17	2000-10-16	강재헌	베타-아미노-알파-하이드록시산과 균등한 옥사졸린 유도체의 입체선택적 합성방법
WO2001030770A1 (en) *	1999-10-26	2001-05-03	Dong Kook Pharmaceutical Co., Ltd.	Stereoselective synthesis of oxazoline derivative
ES2178539B1 (es) *	2000-03-14	2004-08-01	Dong Kook Pharmaceutical Co., Ltd.	Procedimiento para la preparacion de un compuesto de oxazolina.
WO2002066448A1 (en) *	2001-02-20	2002-08-29	Dabur India Limited	Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid
FR2846327B1 (fr) *	2002-10-25	2006-03-24	Merck Sante Sas	Derives de n-benzodioxolyl, n-benzodioxanyl et n-benzodioxepinyl arylcarboxamides utilisables dans le traitement de dyslipidemies et compositions pharmaceutiques les contenant.
KR20080030013A (ko) *	2005-06-10	2008-04-03	플로리다 스테이트 유니버시티 리서치 파운데이션, 인크	폴리시클릭 융합 고리 화합물의 제조 방법
JP5113745B2 (ja) *	2005-06-10	2013-01-09	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	ドセタキセルの製造法
GB0701523D0 (en) *	2007-01-26	2007-03-07	Chatham Biotec Ltd	Semi-synthetic process for the preparation of taxane derivatives
CN101468974B (zh) *	2007-12-28	2011-02-09	上海百灵医药科技有限公司	多烯紫杉醇的半合成方法
RU2014146265A (ru)	2009-12-30	2015-07-10	Басф Фарма (Калланиш) Лимитед	Способ хроматографического разделения с псевдодвижущимся слоем
GB201111595D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	Improved process
GB201111591D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	Further new process
GB201111601D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New process
GB201111589D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New modified process
GB201111594D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New improved process
CN103508918B (zh) *	2012-06-18	2015-09-09	上海医药工业研究院	带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
GB201300354D0 (en)	2013-01-09	2013-02-20	Basf Pharma Callanish Ltd	Multi-step separation process
US9428711B2 (en)	2013-05-07	2016-08-30	Groupe Novasep	Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en)	2013-05-07	2014-08-12	Group Novasep	Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP2883860B1 (de)	2013-12-11	2016-08-24	Novasep Process	Chromatografisches Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren
BR112016015718B1 (pt)	2014-01-07	2021-12-07	Novasep Process Solutions	Processo de purificação de aminoácidos aromáticos
KR20180027559A (ko) *	2015-07-07	2018-03-14	타다카츠 만다이	파클리탁셀 및 도세탁셀의 측쇄 전구체의 제조 방법
CN112876503B (zh) *	2021-03-18	2022-04-29	中国科学院兰州化学物理研究所	用于癌症硼中子俘获治疗药物的硼酸盐化合物及其制备
CN114195820B (zh) *	2021-12-17	2023-11-10	中山大学	异丝氨酸衍生物及其制备与在紫杉醇合成中的应用

Family Cites Families (14)

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US4876399A (en) *	1987-11-02	1989-10-24	Research Corporation Technologies, Inc.	Taxols, their preparation and intermediates thereof
US5008411A (en) *	1988-05-24	1991-04-16	Hoffmann-La Roche Inc.	Glycidic acid ester and process of preparation
US5274300A (en) *	1988-10-26	1993-12-28	Sepracor, Inc.	Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
IL95436A (en) *	1989-08-23	1996-07-23	Centre Nat Rech Scient	Method for the preparation of phenzlisoserine derivatives
US5304670A (en)	1989-08-23	1994-04-19	Centre National De La Recherche Scientifique	Process for the enantioselective preparation of phenylisoserine derivatives
JPH088879B2 (ja) *	1989-09-13	1996-01-31	田辺製薬株式会社	光学活性３―フェニルグリシッド酸エステル類化合物の製法
FR2658513B1 (fr) *	1990-02-21	1994-02-04	Rhone Poulenc Sante	Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
RU2017724C1 (ru) *	1990-07-12	1994-08-15	Дзе Юниверсити оф Канзас	Способ получения производных таксола
FR2678930B1 (fr) *	1991-07-10	1995-01-13	Rhone Poulenc Rorer Sa	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
WO1993010076A1 (en) *	1991-11-22	1993-05-27	The University Of Mississippi	Synthesis and optical resolution of the taxol side chain and related compounds
FR2687150B1 (fr) *	1992-02-07	1995-04-28	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
KR100327625B1 (ko) *	1992-12-23	2002-11-07	브리스톨-마이어스스퀴브컴파니	신규측쇄-함유탁산및그의중간체화합물
FR2740451B1 (fr) *	1995-10-27	1998-01-16	Seripharm	Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US6228955B1 (en) *	1996-04-19	2001-05-08	Chirotech Technology, Ltd.	Asymmetric epoxides, their synthesis and use

1995
- 1995-10-27 FR FR9512739A patent/FR2740451B1/fr not_active Expired - Fee Related
1996
- 1996-10-25 AT AT96934977T patent/ATE212342T1/de not_active IP Right Cessation
- 1996-10-25 GE GEAP19964253A patent/GEP20001938B/en unknown
- 1996-10-25 SK SK523-98A patent/SK52398A3/sk unknown
- 1996-10-25 CZ CZ981255A patent/CZ125598A3/cs unknown
- 1996-10-25 DK DK96934977T patent/DK0863887T3/da active
- 1996-10-25 DE DE69618812T patent/DE69618812T2/de not_active Expired - Lifetime
- 1996-10-25 KR KR1019980703067A patent/KR100489865B1/ko not_active Expired - Fee Related
- 1996-10-25 EE EE9800149A patent/EE03610B1/xx not_active IP Right Cessation
- 1996-10-25 HU HU9802487A patent/HU225507B1/hu not_active IP Right Cessation
- 1996-10-25 PT PT96934977T patent/PT863887E/pt unknown
- 1996-10-25 AU AU73086/96A patent/AU710314B2/en not_active Ceased
- 1996-10-25 BR BR9610908A patent/BR9610908A/pt unknown
- 1996-10-25 WO PCT/FR1996/001676 patent/WO1997015562A1/fr active IP Right Grant
- 1996-10-25 PL PL96327458A patent/PL327458A1/xx unknown
- 1996-10-25 ES ES96934977T patent/ES2170876T3/es not_active Expired - Lifetime
- 1996-10-25 JP JP9516372A patent/JP2000500437A/ja not_active Ceased
- 1996-10-25 US US09/065,041 patent/US6265587B1/en not_active Expired - Fee Related
- 1996-10-25 EP EP96934977A patent/EP0863887B1/de not_active Expired - Lifetime
- 1996-10-25 TR TR1998/00713T patent/TR199800713T2/xx unknown
- 1996-10-25 RU RU98110071/04A patent/RU2159237C2/ru not_active IP Right Cessation
- 1996-10-25 CN CNB961978538A patent/CN100374428C/zh not_active Expired - Fee Related
- 1996-10-25 NZ NZ320356A patent/NZ320356A/xx unknown
1998
- 1998-04-23 NO NO981823A patent/NO981823L/no not_active Application Discontinuation
2001
- 2001-04-18 US US09/836,326 patent/US6825365B2/en not_active Expired - Fee Related
2003
- 2003-05-12 IL IL155876A patent/IL155876A/en not_active IP Right Cessation
2004
- 2004-06-04 US US10/859,953 patent/US7279586B2/en not_active Expired - Fee Related
2005
- 2005-03-11 US US11/076,856 patent/US7220871B2/en not_active Expired - Fee Related
2007
- 2007-03-07 US US11/714,817 patent/US7432383B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ320356A (en)	2000-01-28
EP0863887B1 (de)	2002-01-23
HUP9802487A3 (en)	2000-07-28
TR199800713T2 (xx)	1998-09-21
SK52398A3 (en)	1998-09-09
US7432383B2 (en)	2008-10-07
US20070208185A1 (en)	2007-09-06
EE9800149A (et)	1998-12-15
KR100489865B1 (ko)	2006-01-27
AU7308696A (en)	1997-05-15
PT863887E (pt)	2002-07-31
CN1200731A (zh)	1998-12-02
NO981823D0 (no)	1998-04-23
EE03610B1 (et)	2002-02-15
US6265587B1 (en)	2001-07-24
HU225507B1 (en)	2007-01-29
BR9610908A (pt)	1999-07-13
US20040220256A1 (en)	2004-11-04
US20050222089A1 (en)	2005-10-06
CZ125598A3 (cs)	1998-08-12
US7220871B2 (en)	2007-05-22
US20020068833A1 (en)	2002-06-06
NO981823L (no)	1998-04-23
DE69618812T2 (de)	2002-08-29
US6825365B2 (en)	2004-11-30
DK0863887T3 (da)	2002-04-22
AU710314B2 (en)	1999-09-16
KR19990067124A (ko)	1999-08-16
GEP20001938B (en)	2000-02-05
DE69618812D1 (de)	2002-03-14
RU2159237C2 (ru)	2000-11-20
PL327458A1 (en)	1998-12-07
US7279586B2 (en)	2007-10-09
EP0863887A1 (de)	1998-09-16
IL155876A (en)	2008-07-08
JP2000500437A (ja)	2000-01-18
ES2170876T3 (es)	2002-08-16
HUP9802487A2 (hu)	1999-09-28
FR2740451A1 (fr)	1997-04-30
WO1997015562A1 (fr)	1997-05-01
CN100374428C (zh)	2008-03-12
FR2740451B1 (fr)	1998-01-16

Publication	Publication Date	Title
ATE212342T1 (de)	2002-02-15	Zwischerprodukte für die hemisynthese von taxanen und deren verfahren zu herstellung
NO303574B1 (no)	1998-08-03	Ny fremgangsmÕte for fremstilling av 9-amino-6-demetyl-6-deoksytetracykliner
ATE260919T1 (de)	2004-03-15	Zwischenprodukte für die herstellung von pharmazeutischem camptothecin
HU9300594D0 (en)	1993-05-28	Method for producing baccatine-iii derivatives
DE59606920D1 (de)	2001-06-21	Chirale methylphenyloxazolidinone
RU92016321A (ru)	1996-09-10	Способ энантиоселективного получения производных фенилизосерина, применение производных для получения производных таксана и производные таксана
OA08919A (fr)	1989-10-31	Procédé de production de dérivés substitués de tétraline, chromanes et composés apparentés.
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