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PE20181336A1 - Anticuerpos que se unen a interleucina 8 (il-8) y sus usos - Google Patents

Anticuerpos que se unen a interleucina 8 (il-8) y sus usos

Info

Publication number
PE20181336A1
PE20181336A1 PE2018000378A PE2018000378A PE20181336A1 PE 20181336 A1 PE20181336 A1 PE 20181336A1 PE 2018000378 A PE2018000378 A PE 2018000378A PE 2018000378 A PE2018000378 A PE 2018000378A PE 20181336 A1 PE20181336 A1 PE 20181336A1
Authority
PE
Peru
Prior art keywords
hvr
seq
antibodies
bind interleukin
interleukin
Prior art date
Application number
PE2018000378A
Other languages
English (en)
Inventor
Tomoyuki Igawa
Atsuhiko Maeda
Genki Nakamura
Masaru Muraoka
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of PE20181336A1 publication Critical patent/PE20181336A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

Referido a un anticuerpo anti-IL-8 que se une a una interleucina-8 humana de manera dependiente de pH, caracterizado porque comprende como minimo una sustitucion de aminoacidos en uno de : a) HVR-H1 que comprende la secuencia de aminoacidos SEC ID NO: 67; b) HVR-H2 que comprende la SEC ID NO: 68; c) HVR-H3 que comprende la SEC ID NO: 69; d) HVR-L1 que comprende la SEC ID NO:70; e) HVR-L2 que comprende la SEC ID NO: 71; y f) HVR-L3 que comprende la SEC ID NO: 72. Tambien se refiere a composiciones, metodos y uso en el tratamiento de enfermedades o trastornos relacionados con la presencia excesiva de IL-8, tal como inhibidor de la angiogenesis.
PE2018000378A 2015-09-18 2016-08-05 Anticuerpos que se unen a interleucina 8 (il-8) y sus usos PE20181336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015185254 2015-09-18

Publications (1)

Publication Number Publication Date
PE20181336A1 true PE20181336A1 (es) 2018-08-21

Family

ID=56738152

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000378A PE20181336A1 (es) 2015-09-18 2016-08-05 Anticuerpos que se unen a interleucina 8 (il-8) y sus usos

Country Status (22)

Country Link
EP (1) EP3350202A1 (es)
JP (5) JP6266164B2 (es)
KR (4) KR20250016474A (es)
CN (2) CN108271372B (es)
AR (1) AR105634A1 (es)
AU (1) AU2016323088B2 (es)
BR (1) BR112018002432A2 (es)
CA (1) CA2993423C (es)
CL (1) CL2018000699A1 (es)
CO (1) CO2018004056A2 (es)
CR (1) CR20180217A (es)
IL (2) IL258088B2 (es)
MA (1) MA42808A (es)
MX (2) MX2018003005A (es)
MY (1) MY203894A (es)
PE (1) PE20181336A1 (es)
PH (1) PH12018500386B1 (es)
RU (1) RU2728430C2 (es)
TW (5) TWI751300B (es)
UA (1) UA120981C2 (es)
WO (1) WO2017046994A1 (es)
ZA (1) ZA201800536B (es)

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TWI855488B (zh) 2012-08-24 2024-09-11 日商中外製藥股份有限公司 FcγRIIb特異性Fc區域變異體
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BR112015024587B1 (pt) 2013-04-02 2022-11-29 Chugai Seiyaku Kabushiki Kaisha Variante de região fc de igg1 humana, polipeptídeo compreendendo a mesma, seu método de produção e composição farmacêutica
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KR102102734B1 (ko) * 2016-08-05 2020-04-22 추가이 세이야쿠 가부시키가이샤 Il-8 관련 질환의 치료용 또는 예방용 조성물
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IL317002A (en) 2018-08-10 2025-01-01 Chugai Pharmaceutical Co Ltd Anti-CD137 antigen binding molecule and use thereof
EP3956365A4 (en) * 2019-04-19 2023-07-05 Chugai Seiyaku Kabushiki Kaisha ANTIBODIES AND COMPOSITIONS FOR USE IN DETECTING OR CAPTURING A POLYPEPTIDE IN A SAMPLE, AND METHODS FOR DETECTING OR CAPTURING A POLYPEPTIDE IN A SAMPLE
EP4076663A1 (en) 2019-12-18 2022-10-26 F. Hoffmann-La Roche AG Bispecific anti-ccl2 antibodies
TWI870543B (zh) 2020-01-31 2025-01-21 日商中外製藥股份有限公司 含有抑制著色之多肽的組成物之製造方法
CA3167808A1 (en) 2020-02-12 2021-08-19 Chugai Seiyaku Kabushiki Kaisha Anti-cd137 antigen-binding molecule for use in cancer treatment
KR20230005156A (ko) * 2020-04-17 2023-01-09 조에티스 서비시즈 엘엘씨 개과 항체 변이체
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KR20230047397A (ko) * 2020-07-28 2023-04-07 추가이 세이야쿠 가부시키가이샤 신규 개변형 항체를 포함하는, 바늘 실드를 구비한 바늘 부가 프리필드 시린지 제제
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