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SA519401494B1 - مستقبلات مولد ضد كيمري لعلاج سرطان - Google Patents

مستقبلات مولد ضد كيمري لعلاج سرطان

Info

Publication number
SA519401494B1
SA519401494B1 SA519401494A SA519401494A SA519401494B1 SA 519401494 B1 SA519401494 B1 SA 519401494B1 SA 519401494 A SA519401494 A SA 519401494A SA 519401494 A SA519401494 A SA 519401494A SA 519401494 B1 SA519401494 B1 SA 519401494B1
Authority
SA
Saudi Arabia
Prior art keywords
car
chimeric antigen
cancer
treatment
antigen receptors
Prior art date
Application number
SA519401494A
Other languages
English (en)
Inventor
برانيتي باربارا
جراندا براين
إنجلز بوريس
زانغ جيمين
بروجدون جينيفر
إم. يونج ريجينا
جيل سار
غيماريس كارلا
هوانج لو
رويلا ماركو
لي مينغ
لي نا
Original Assignee
ذا تراستيس اوف ذا يونيفيرستي اوف بنسيلفانيا
نوفارتيس أيه جي
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ذا تراستيس اوف ذا يونيفيرستي اوف بنسيلفانيا, نوفارتيس أيه جي filed Critical ذا تراستيس اوف ذا يونيفيرستي اوف بنسيلفانيا
Publication of SA519401494B1 publication Critical patent/SA519401494B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/001111—Immunoglobulin superfamily
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    • A61K39/001111—Immunoglobulin superfamily
    • A61K39/001113—CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Abstract

يقدم الاختراع تركيبات وطرق لعلاج الأمراض المرتبطة بالتعبير عن CD20 أو CD22. يتعلق الاختراع أيضا بمستقبل مولد ضد كيمري (CAR) انتقائي لـ CD20 أو CD22، موجهات ترمزها، وخلايا T ناتج عودة الارتباط الجيني أو خلايا قتل طبيعي (NK) تتضمن CD20 CAR أو CD22 CAR. يتضمن الاختراع أيضا طرق إعطاء خلية T معدلة جينيا أو خلية NK تعبر عن CAR تتضمن نطاق ربط CD20 أو CD22. انظر الشكل 1
SA519401494A 2016-10-07 2019-04-04 مستقبلات مولد ضد كيمري لعلاج سرطان SA519401494B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662405520P 2016-10-07 2016-10-07

Publications (1)

Publication Number Publication Date
SA519401494B1 true SA519401494B1 (ar) 2023-11-12

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ID=60294397

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Application Number Title Priority Date Filing Date
SA519401494A SA519401494B1 (ar) 2016-10-07 2019-04-04 مستقبلات مولد ضد كيمري لعلاج سرطان

Country Status (18)

Country Link
US (5) US10525083B2 (ar)
EP (1) EP3523331A1 (ar)
JP (3) JP7467117B2 (ar)
KR (2) KR20240153612A (ar)
CN (2) CN117866991A (ar)
AR (2) AR110676A1 (ar)
AU (2) AU2017341047B2 (ar)
BR (1) BR112019006781A2 (ar)
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