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WO2018169153A1 - Composition contenant en tant que principe actif un agent bloquant l'acide par compétition avec le potassium, pour le traitement et la prévention du syndrome de l'intestin perméable - Google Patents

Composition contenant en tant que principe actif un agent bloquant l'acide par compétition avec le potassium, pour le traitement et la prévention du syndrome de l'intestin perméable Download PDF

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Publication number
WO2018169153A1
WO2018169153A1 PCT/KR2017/010349 KR2017010349W WO2018169153A1 WO 2018169153 A1 WO2018169153 A1 WO 2018169153A1 KR 2017010349 W KR2017010349 W KR 2017010349W WO 2018169153 A1 WO2018169153 A1 WO 2018169153A1
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WO
WIPO (PCT)
Prior art keywords
treatment
composition
leaky gut
gut syndrome
cab
Prior art date
Application number
PCT/KR2017/010349
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English (en)
Korean (ko)
Inventor
함기백
박종민
한영민
박용진
Original Assignee
차의과학대학교 산학협력단
지아이메딕스 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 차의과학대학교 산학협력단, 지아이메딕스 주식회사 filed Critical 차의과학대학교 산학협력단
Publication of WO2018169153A1 publication Critical patent/WO2018169153A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Definitions

  • each tissue was scored on the basis of villi loss, ulceration, inflammation, and the like, when viewed pathologically as an animal tissue, and the results are shown in FIG. 6.
  • severe vili loss and inflammation were observed, with similar findings in the group receiving PPI.
  • the group receiving P-CAB showed more improvement in vili loss and inflammation.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition capable de prévenir et de traiter efficacement le syndrome de l'intestin perméable ou le syndrome de l'intestin perméable induit par un médicament anti-inflammatoire non stéroïdien (AINS), la composition contenant en tant que principe actif un agent bloquant l'acide par compétition avec le potassium (p-cab, pour "potassium-competitive acid blocker").
PCT/KR2017/010349 2017-03-16 2017-09-20 Composition contenant en tant que principe actif un agent bloquant l'acide par compétition avec le potassium, pour le traitement et la prévention du syndrome de l'intestin perméable WO2018169153A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170033118A KR20180107341A (ko) 2017-03-16 2017-03-16 칼륨 경쟁적 위산분비억제제를 유효성분을 함유하는 장 누수 증후군 치료 및 예방용 조성물
KR10-2017-0033118 2017-03-16

Publications (1)

Publication Number Publication Date
WO2018169153A1 true WO2018169153A1 (fr) 2018-09-20

Family

ID=63522412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/010349 WO2018169153A1 (fr) 2017-03-16 2017-09-20 Composition contenant en tant que principe actif un agent bloquant l'acide par compétition avec le potassium, pour le traitement et la prévention du syndrome de l'intestin perméable

Country Status (2)

Country Link
KR (1) KR20180107341A (fr)
WO (1) WO2018169153A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100010412A1 (it) 2021-04-26 2022-10-26 Anseris Farma S R L Composizione per il trattamento dell’intestino irritabile e della sindrome metabolica correlata alle alterazioni della permeabilità intestinale.

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022512813A (ja) * 2018-11-02 2022-02-07 フォーディー ファーマ リサーチ リミテッド 細菌株を含む組成物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010056078A1 (en) * 2000-02-11 2001-12-27 Norton Healthcare Limited Novel method for treating gut disorders using polyanionic polyglycosides
KR20070057663A (ko) * 2005-12-01 2007-06-07 주식회사유한양행 위장관 점막 손상의 예방 또는 치료용 조성물
US8183211B2 (en) * 2000-05-19 2012-05-22 University Of Maryland, Baltimore Pharmaceutical compositions for inhibiting intestinal permeability
US20150057349A1 (en) * 2012-03-30 2015-02-26 Nestec S.A. 4-oxo-2-pentenoic acid and the health of the digestive tract
US20150258151A1 (en) * 2012-12-07 2015-09-17 Albert Einstein College Of Medicine Of Yeshiva University Gut barrier dysfunction treatment and prevention

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010056078A1 (en) * 2000-02-11 2001-12-27 Norton Healthcare Limited Novel method for treating gut disorders using polyanionic polyglycosides
US8183211B2 (en) * 2000-05-19 2012-05-22 University Of Maryland, Baltimore Pharmaceutical compositions for inhibiting intestinal permeability
KR20070057663A (ko) * 2005-12-01 2007-06-07 주식회사유한양행 위장관 점막 손상의 예방 또는 치료용 조성물
US20150057349A1 (en) * 2012-03-30 2015-02-26 Nestec S.A. 4-oxo-2-pentenoic acid and the health of the digestive tract
US20150258151A1 (en) * 2012-12-07 2015-09-17 Albert Einstein College Of Medicine Of Yeshiva University Gut barrier dysfunction treatment and prevention

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHA CANCER PREVENTION RESEARCH CENTER, CHA CANCER INSTITUTE, CHA UNIVERSITY ET AL.: "Indomethacin-induced Leaky Gut Syndrome Aggravated by Pantoprazole, but Not by Revaprazan: PPI Aggravated, but p-CAB Relieved NSAID-induced Intestinal Permeability", THE 10TH INTERNATIONAL GASTROINTESTINAL CONSENSUS SYMPOSIUM, vol. 4, 18 February 2017 (2017-02-18), pages 104 - 4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100010412A1 (it) 2021-04-26 2022-10-26 Anseris Farma S R L Composizione per il trattamento dell’intestino irritabile e della sindrome metabolica correlata alle alterazioni della permeabilità intestinale.

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Publication number Publication date
KR20180107341A (ko) 2018-10-02

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